Distinct prognostic value of circulating anti-telomerase CD4(+) Th1 immunity and exhausted PD-1(+)/TIM-3(+) T cells in lung cancer

BACKGROUND: Despite the critical roles of Th1-polarised CD4(+) T cells in cancer immunosurveillance, the translation of their potential to clinical use remains challenging. Here, we investigate the clinical relevance of circulating antitumor Th1 immunity in non-small cell lung cancer (NSCLC). METHOD...

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Detalles Bibliográficos
Autores principales: Laheurte, Caroline, Dosset, Magalie, Vernerey, Dewi, Boullerot, Laura, Gaugler, Béatrice, Gravelin, Eléonore, Kaulek, Vincent, Jacquin, Marion, Cuche, Laurie, Eberst, Guillaume, Jacoulet, Pascale, Fabre, Elizabeth, Le Pimpec-Barthes, Françoise, Tartour, Eric, De Carvalho Bittencourt, Marcelo, Westeel, Virginie, Adotévi, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738094/
https://www.ncbi.nlm.nih.gov/pubmed/31358938
http://dx.doi.org/10.1038/s41416-019-0531-5

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