Targeting CXCL12/CXCR4 and myeloid cells to improve the therapeutic ratio in patient-derived cervical cancer models treated with radio-chemotherapy

BACKGROUND: The CXCL12/CXCR4 chemokine pathway is involved in cervical cancer pathogenesis and radiation treatment (RT) response. We previously reported that radiochemotherapy (RTCT) and concurrent administration of the CXCR4 inhibitor plerixafor improved primary tumour response. The aims of this st...

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Detalles Bibliográficos
Autores principales: Lecavalier-Barsoum, Magali, Chaudary, Naz, Han, Kathy, Pintilie, Melania, Hill, Richard P., Milosevic, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738100/
https://www.ncbi.nlm.nih.gov/pubmed/31239542
http://dx.doi.org/10.1038/s41416-019-0497-3

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