Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion

Neonatal soft tissues sarcoma is a rare entity that comprises heterogeneous types of tumors. In this article we describe a neonatal case of round-cell sarcoma with an YWHAE-NUTM2B fusion gene. The patient was treated just after birth with neoadjuvant chemotherapy, then surgical resection, but evolut...

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Detalles Bibliográficos
Autores principales: Guizard, Maylis, Karanian, Marie, Dijoud, Frédérique, Bouhamama, Amine, Faure-Conter, Cécile, Hameury, Frédéric, Tirode, Franck, Corradini, Nadège
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738155/
https://www.ncbi.nlm.nih.gov/pubmed/31543780
http://dx.doi.org/10.1159/000502227
Descripción
Sumario:Neonatal soft tissues sarcoma is a rare entity that comprises heterogeneous types of tumors. In this article we describe a neonatal case of round-cell sarcoma with an YWHAE-NUTM2B fusion gene. The patient was treated just after birth with neoadjuvant chemotherapy, then surgical resection, but evolution was quickly fatal. This fusion transcript has been reported in endometrial stromal sarcomas and clear cells renal sarcomas but its description in small round-cell sarcomas is recent. To our knowledge, this is the first case report describing this translocation in a newborn patient with soft tissues sarcoma and its clinical tumoral evolution.

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