Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion

Neonatal soft tissues sarcoma is a rare entity that comprises heterogeneous types of tumors. In this article we describe a neonatal case of round-cell sarcoma with an YWHAE-NUTM2B fusion gene. The patient was treated just after birth with neoadjuvant chemotherapy, then surgical resection, but evolut...

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Autores principales: Guizard, Maylis, Karanian, Marie, Dijoud, Frédérique, Bouhamama, Amine, Faure-Conter, Cécile, Hameury, Frédéric, Tirode, Franck, Corradini, Nadège
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738155/
https://www.ncbi.nlm.nih.gov/pubmed/31543780
http://dx.doi.org/10.1159/000502227
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author Guizard, Maylis
Karanian, Marie
Dijoud, Frédérique
Bouhamama, Amine
Faure-Conter, Cécile
Hameury, Frédéric
Tirode, Franck
Corradini, Nadège
author_facet Guizard, Maylis
Karanian, Marie
Dijoud, Frédérique
Bouhamama, Amine
Faure-Conter, Cécile
Hameury, Frédéric
Tirode, Franck
Corradini, Nadège
author_sort Guizard, Maylis
collection PubMed
description Neonatal soft tissues sarcoma is a rare entity that comprises heterogeneous types of tumors. In this article we describe a neonatal case of round-cell sarcoma with an YWHAE-NUTM2B fusion gene. The patient was treated just after birth with neoadjuvant chemotherapy, then surgical resection, but evolution was quickly fatal. This fusion transcript has been reported in endometrial stromal sarcomas and clear cells renal sarcomas but its description in small round-cell sarcomas is recent. To our knowledge, this is the first case report describing this translocation in a newborn patient with soft tissues sarcoma and its clinical tumoral evolution.
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spelling pubmed-67381552019-09-22 Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion Guizard, Maylis Karanian, Marie Dijoud, Frédérique Bouhamama, Amine Faure-Conter, Cécile Hameury, Frédéric Tirode, Franck Corradini, Nadège Case Rep Oncol Case Report Neonatal soft tissues sarcoma is a rare entity that comprises heterogeneous types of tumors. In this article we describe a neonatal case of round-cell sarcoma with an YWHAE-NUTM2B fusion gene. The patient was treated just after birth with neoadjuvant chemotherapy, then surgical resection, but evolution was quickly fatal. This fusion transcript has been reported in endometrial stromal sarcomas and clear cells renal sarcomas but its description in small round-cell sarcomas is recent. To our knowledge, this is the first case report describing this translocation in a newborn patient with soft tissues sarcoma and its clinical tumoral evolution. S. Karger AG 2019-08-08 /pmc/articles/PMC6738155/ /pubmed/31543780 http://dx.doi.org/10.1159/000502227 Text en Copyright © 2019 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Guizard, Maylis
Karanian, Marie
Dijoud, Frédérique
Bouhamama, Amine
Faure-Conter, Cécile
Hameury, Frédéric
Tirode, Franck
Corradini, Nadège
Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion
title Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion
title_full Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion
title_fullStr Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion
title_full_unstemmed Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion
title_short Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion
title_sort neonatal soft tissue sarcoma with ywhae-nutm2b fusion
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738155/
https://www.ncbi.nlm.nih.gov/pubmed/31543780
http://dx.doi.org/10.1159/000502227
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