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Bilateral Ear Swelling and Erythema after Chemotherapy: A Case Report of Ara-C Ears

Cytarabine is an antimetabolite commonly used to treat hematological malignancies, especially acute myeloid leukemia (AML), acute lymphoblastic leukemia, and non-Hodgkin's lymphoma. Cytarabine-induced cutaneous adverse effects are common, usually manifesting as morbilliform eruptions predominan...

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Detalles Bibliográficos
Autores principales: Jaruvijitrattana, Pitchaya, Chanprapaph, Kumutnart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738253/
https://www.ncbi.nlm.nih.gov/pubmed/31543769
http://dx.doi.org/10.1159/000501876
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author Jaruvijitrattana, Pitchaya
Chanprapaph, Kumutnart
author_facet Jaruvijitrattana, Pitchaya
Chanprapaph, Kumutnart
author_sort Jaruvijitrattana, Pitchaya
collection PubMed
description Cytarabine is an antimetabolite commonly used to treat hematological malignancies, especially acute myeloid leukemia (AML), acute lymphoblastic leukemia, and non-Hodgkin's lymphoma. Cytarabine-induced cutaneous adverse effects are common, usually manifesting as morbilliform eruptions predominantly on the acral site, intertriginous zone, and to a lesser extent on the elbows, knees, neck, and ears. The presentation on ears is usually called “Ara-C ears,” which is considered as a rare subtype of acral erythema. We report a 53-year-old Thai woman with AML who developed cytarabine-induced rashes. The lesions began on symmetrical bilateral ears, posterior auricular areas, and forehead followed by expansion to the trunk and extremities. The clinical presentations and histopathological findings were compatible with toxic erythema of chemotherapy. After giving cetirizine 10 mg orally twice daily and 0.1% triamcinolone acetonide cream twice daily, the lesions gradually improved over 10 days. Notably, two additional courses of high-dose cytarabine were administered without any recurrence.
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spelling pubmed-67382532019-09-22 Bilateral Ear Swelling and Erythema after Chemotherapy: A Case Report of Ara-C Ears Jaruvijitrattana, Pitchaya Chanprapaph, Kumutnart Case Rep Dermatol Single Case Cytarabine is an antimetabolite commonly used to treat hematological malignancies, especially acute myeloid leukemia (AML), acute lymphoblastic leukemia, and non-Hodgkin's lymphoma. Cytarabine-induced cutaneous adverse effects are common, usually manifesting as morbilliform eruptions predominantly on the acral site, intertriginous zone, and to a lesser extent on the elbows, knees, neck, and ears. The presentation on ears is usually called “Ara-C ears,” which is considered as a rare subtype of acral erythema. We report a 53-year-old Thai woman with AML who developed cytarabine-induced rashes. The lesions began on symmetrical bilateral ears, posterior auricular areas, and forehead followed by expansion to the trunk and extremities. The clinical presentations and histopathological findings were compatible with toxic erythema of chemotherapy. After giving cetirizine 10 mg orally twice daily and 0.1% triamcinolone acetonide cream twice daily, the lesions gradually improved over 10 days. Notably, two additional courses of high-dose cytarabine were administered without any recurrence. S. Karger AG 2019-07-25 /pmc/articles/PMC6738253/ /pubmed/31543769 http://dx.doi.org/10.1159/000501876 Text en Copyright © 2019 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Jaruvijitrattana, Pitchaya
Chanprapaph, Kumutnart
Bilateral Ear Swelling and Erythema after Chemotherapy: A Case Report of Ara-C Ears
title Bilateral Ear Swelling and Erythema after Chemotherapy: A Case Report of Ara-C Ears
title_full Bilateral Ear Swelling and Erythema after Chemotherapy: A Case Report of Ara-C Ears
title_fullStr Bilateral Ear Swelling and Erythema after Chemotherapy: A Case Report of Ara-C Ears
title_full_unstemmed Bilateral Ear Swelling and Erythema after Chemotherapy: A Case Report of Ara-C Ears
title_short Bilateral Ear Swelling and Erythema after Chemotherapy: A Case Report of Ara-C Ears
title_sort bilateral ear swelling and erythema after chemotherapy: a case report of ara-c ears
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738253/
https://www.ncbi.nlm.nih.gov/pubmed/31543769
http://dx.doi.org/10.1159/000501876
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