G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease?

Parkinson’s disease (PD) is the second most common neurodegenerative disorder and has plagued humans for more than 200 years. The etiology and detailed pathogenesis of PD is unclear, but is currently believed to be the result of the interaction between genetic and environmental factors. Studies have...

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Autores principales: Ren, Chao, Ding, Yu, Wei, Shizhuang, Guan, Lina, Zhang, Caiyi, Ji, Yongqiang, Wang, Fen, Yin, Shaohua, Yin, Peiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738350/
https://www.ncbi.nlm.nih.gov/pubmed/31551736
http://dx.doi.org/10.3389/fnhum.2019.00306
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author Ren, Chao
Ding, Yu
Wei, Shizhuang
Guan, Lina
Zhang, Caiyi
Ji, Yongqiang
Wang, Fen
Yin, Shaohua
Yin, Peiyuan
author_facet Ren, Chao
Ding, Yu
Wei, Shizhuang
Guan, Lina
Zhang, Caiyi
Ji, Yongqiang
Wang, Fen
Yin, Shaohua
Yin, Peiyuan
author_sort Ren, Chao
collection PubMed
description Parkinson’s disease (PD) is the second most common neurodegenerative disorder and has plagued humans for more than 200 years. The etiology and detailed pathogenesis of PD is unclear, but is currently believed to be the result of the interaction between genetic and environmental factors. Studies have found that PD patients with the LRRK2:G2019S variation have the typical clinical manifestations of PD, which may be familial or sporadic, and have age-dependent pathogenic characteristics. Therefore, the LRRK2:G2019S variation may be an ideal model to study the interaction of multiple factors such as genetic, environmental and natural aging factors in PD in the future. This article reviewed the progress of LRRK2:G2019S studies in PD research in order to provide new research ideas and directions for the pathogenesis and treatment of PD.
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spelling pubmed-67383502019-09-24 G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease? Ren, Chao Ding, Yu Wei, Shizhuang Guan, Lina Zhang, Caiyi Ji, Yongqiang Wang, Fen Yin, Shaohua Yin, Peiyuan Front Hum Neurosci Neuroscience Parkinson’s disease (PD) is the second most common neurodegenerative disorder and has plagued humans for more than 200 years. The etiology and detailed pathogenesis of PD is unclear, but is currently believed to be the result of the interaction between genetic and environmental factors. Studies have found that PD patients with the LRRK2:G2019S variation have the typical clinical manifestations of PD, which may be familial or sporadic, and have age-dependent pathogenic characteristics. Therefore, the LRRK2:G2019S variation may be an ideal model to study the interaction of multiple factors such as genetic, environmental and natural aging factors in PD in the future. This article reviewed the progress of LRRK2:G2019S studies in PD research in order to provide new research ideas and directions for the pathogenesis and treatment of PD. Frontiers Media S.A. 2019-09-04 /pmc/articles/PMC6738350/ /pubmed/31551736 http://dx.doi.org/10.3389/fnhum.2019.00306 Text en Copyright © 2019 Ren, Ding, Wei, Guan, Zhang, Ji, Wang, Yin and Yin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ren, Chao
Ding, Yu
Wei, Shizhuang
Guan, Lina
Zhang, Caiyi
Ji, Yongqiang
Wang, Fen
Yin, Shaohua
Yin, Peiyuan
G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease?
title G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease?
title_full G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease?
title_fullStr G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease?
title_full_unstemmed G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease?
title_short G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease?
title_sort g2019s variation in lrrk2: an ideal model for the study of parkinson’s disease?
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738350/
https://www.ncbi.nlm.nih.gov/pubmed/31551736
http://dx.doi.org/10.3389/fnhum.2019.00306
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