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Comparison between silicon photomultiplier-based and conventional PET/CT in patients with suspected lung cancer—a pilot study

BACKGROUND: Lung cancer is one of the most common cancers in the world. Early detection and correct staging are fundamental for treatment and prognosis. Positron emission tomography with computed tomography (PET/CT) is recommended clinically. Silicon (Si) photomultiplier (PM)-based PET technology an...

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Autores principales: Economou Lundeberg, Johan, Oddstig, Jenny, Bitzén, Ulrika, Trägårdh, Elin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738366/
https://www.ncbi.nlm.nih.gov/pubmed/31511997
http://dx.doi.org/10.1186/s13550-019-0504-y
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author Economou Lundeberg, Johan
Oddstig, Jenny
Bitzén, Ulrika
Trägårdh, Elin
author_facet Economou Lundeberg, Johan
Oddstig, Jenny
Bitzén, Ulrika
Trägårdh, Elin
author_sort Economou Lundeberg, Johan
collection PubMed
description BACKGROUND: Lung cancer is one of the most common cancers in the world. Early detection and correct staging are fundamental for treatment and prognosis. Positron emission tomography with computed tomography (PET/CT) is recommended clinically. Silicon (Si) photomultiplier (PM)-based PET technology and new reconstruction algorithms are hoped to increase the detection of small lesions and enable earlier detection of pathologies including metastatic spread. The aim of this study was to compare the diagnostic performance of a SiPM-based PET/CT (including a new block-sequential regularization expectation maximization (BSREM) reconstruction algorithm) with a conventional PM-based PET/CT including a conventional ordered subset expectation maximization (OSEM) reconstruction algorithm. The focus was patients admitted for (18)F-fluorodeoxyglucose (FDG) PET/CT for initial diagnosis and staging of suspected lung cancer. Patients were scanned on both a SiPM-based PET/CT (Discovery MI; GE Healthcare, Milwaukee, MI, USA) and a PM-based PET/CT (Discovery 690; GE Healthcare, Milwaukee, MI, USA). Standardized uptake values (SUV) and image interpretation were compared between the two systems. Image interpretations were further compared with histopathology when available. RESULTS: Seventeen patients referred for suspected lung cancer were included in our single injection, dual imaging study. No statically significant differences in SUV(max) of suspected malignant primary tumours were found between the two PET/CT systems. SUV(max) in suspected malignant intrathoracic lymph nodes was 10% higher on the SiPM-based system (p = 0.026). Good consistency (14/17 cases) between the PET/CT systems were found when comparing simplified TNM staging. The available histology results did not find any obvious differences between the systems. CONCLUSION: In a clinical setting, the new SiPM-based PET/CT system with a new BSREM reconstruction algorithm provided a higher SUV(max) for suspected lymph node metastases compared to the PM-based system. However, no improvement in lung cancer detection was seen.
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spelling pubmed-67383662019-09-25 Comparison between silicon photomultiplier-based and conventional PET/CT in patients with suspected lung cancer—a pilot study Economou Lundeberg, Johan Oddstig, Jenny Bitzén, Ulrika Trägårdh, Elin EJNMMI Res Original Research BACKGROUND: Lung cancer is one of the most common cancers in the world. Early detection and correct staging are fundamental for treatment and prognosis. Positron emission tomography with computed tomography (PET/CT) is recommended clinically. Silicon (Si) photomultiplier (PM)-based PET technology and new reconstruction algorithms are hoped to increase the detection of small lesions and enable earlier detection of pathologies including metastatic spread. The aim of this study was to compare the diagnostic performance of a SiPM-based PET/CT (including a new block-sequential regularization expectation maximization (BSREM) reconstruction algorithm) with a conventional PM-based PET/CT including a conventional ordered subset expectation maximization (OSEM) reconstruction algorithm. The focus was patients admitted for (18)F-fluorodeoxyglucose (FDG) PET/CT for initial diagnosis and staging of suspected lung cancer. Patients were scanned on both a SiPM-based PET/CT (Discovery MI; GE Healthcare, Milwaukee, MI, USA) and a PM-based PET/CT (Discovery 690; GE Healthcare, Milwaukee, MI, USA). Standardized uptake values (SUV) and image interpretation were compared between the two systems. Image interpretations were further compared with histopathology when available. RESULTS: Seventeen patients referred for suspected lung cancer were included in our single injection, dual imaging study. No statically significant differences in SUV(max) of suspected malignant primary tumours were found between the two PET/CT systems. SUV(max) in suspected malignant intrathoracic lymph nodes was 10% higher on the SiPM-based system (p = 0.026). Good consistency (14/17 cases) between the PET/CT systems were found when comparing simplified TNM staging. The available histology results did not find any obvious differences between the systems. CONCLUSION: In a clinical setting, the new SiPM-based PET/CT system with a new BSREM reconstruction algorithm provided a higher SUV(max) for suspected lymph node metastases compared to the PM-based system. However, no improvement in lung cancer detection was seen. Springer Berlin Heidelberg 2019-09-09 /pmc/articles/PMC6738366/ /pubmed/31511997 http://dx.doi.org/10.1186/s13550-019-0504-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Economou Lundeberg, Johan
Oddstig, Jenny
Bitzén, Ulrika
Trägårdh, Elin
Comparison between silicon photomultiplier-based and conventional PET/CT in patients with suspected lung cancer—a pilot study
title Comparison between silicon photomultiplier-based and conventional PET/CT in patients with suspected lung cancer—a pilot study
title_full Comparison between silicon photomultiplier-based and conventional PET/CT in patients with suspected lung cancer—a pilot study
title_fullStr Comparison between silicon photomultiplier-based and conventional PET/CT in patients with suspected lung cancer—a pilot study
title_full_unstemmed Comparison between silicon photomultiplier-based and conventional PET/CT in patients with suspected lung cancer—a pilot study
title_short Comparison between silicon photomultiplier-based and conventional PET/CT in patients with suspected lung cancer—a pilot study
title_sort comparison between silicon photomultiplier-based and conventional pet/ct in patients with suspected lung cancer—a pilot study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738366/
https://www.ncbi.nlm.nih.gov/pubmed/31511997
http://dx.doi.org/10.1186/s13550-019-0504-y
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