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Prediction of Drug–Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation

BACKGROUND: Researchers have long been interested in the potential drug–drug interactions (DDIs) between opioids and benzodiazepines. However, much remains unknown concerning the interactions between these two drug classes. The objective of this work is to study the mechanism underlying the DDIs bet...

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Detalles Bibliográficos
Autores principales:	Ji, Beihong, Liu, Shuhan, Xue, Ying, He, Xibing, Man, Viet Hoang, Xie, Xiang-Qun, Wang, Junmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2019
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738369/ https://www.ncbi.nlm.nih.gov/pubmed/31482303 http://dx.doi.org/10.1007/s40268-019-00282-3

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