Cargando…

Elevated kindlin-2 promotes tumour progression and angiogenesis through the mTOR/VEGFA pathway in melanoma

Background: In our previous study, kindlin-2 promoted skin wound healing and decreased the permeability of neovascularization during angiogenesis. Herein, we explored the biological function and underlying mechanism of kindlin-2 in cutaneous melanoma. Methods and Results: Through a series of in vitr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Chuan-Yuan, Zhu, Meng-Xuan, Zhang, Peng-Fei, Yang, Xuan, Wang, Lu, Ying, Jiang-Hui, Luan, Wen-Jie, Chen, Cheng, Liu, Jia-Qi, Zhu, Ming, Yang, Yan-wen, Feng, Zi-Hao, Qi, Fa-Zhi, Gu, Jian-Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738412/ https://www.ncbi.nlm.nih.gov/pubmed/31427543 http://dx.doi.org/10.18632/aging.102187

Ejemplares similares

Knockdown of the KINDLIN-2 Gene and Reduced Expression of Kindlin-2 Affects Vascular Permeability in Angiogenesis in a Mouse Model of Wound Healing
por: Ying, Jianghui, et al.
Publicado: (2018)

TRIM44 activates the AKT/mTOR signal pathway to induce melanoma progression by stabilizing TLR4
por: Wei, Chuan-Yuan, et al.
Publicado: (2019)

Kindlin-2 suppresses cervical cancer cell migration through AKT/mTOR-mediated autophagy induction
por: Wu, Guangteng, et al.
Publicado: (2020)

HULC long noncoding RNA silencing suppresses angiogenesis by regulating ESM-1 via the PI3K/Akt/mTOR signaling pathway in human gliomas
por: Zhu, Yu, et al.
Publicado: (2016)

Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway
por: Hu, Fuqing, et al.
Publicado: (2018)

Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model
por: Britto, Denver D., et al.
Publicado: (2018)

Opposite Role of Kindlin-1 and Kindlin-2 in Lung Cancers
por: Zhan, Jun, et al.
Publicado: (2012)

ZLM-7 inhibits the occurrence and angiogenesis of breast cancer through miR-212-3p/Sp1/VEGFA signal axis
por: Li, Xuan, et al.
Publicado: (2020)

Downregulation of microRNA-195 promotes angiogenesis induced by cerebral infarction via targeting VEGFA
por: Zhao, Wen-Jing, et al.
Publicado: (2017)

[Retracted] Downregulation of microRNA‑195 promotes angiogenesis induced by cerebral infarction via targeting VEGFA
por: Zhao, Wen-Jing, et al.
Publicado: (2023)

MicroRNA-200c affects bladder cancer angiogenesis by regulating the Akt2/mTOR/HIF-1 axis
por: Wu, Shui-Qing, et al.
Publicado: (2019)

Of Kindlins and Cancer
por: Plow, Edward F., et al.
Publicado: (2016)

Recent Advances in Dual PI3K/mTOR Inhibitors for Tumour Treatment
por: Wu, Xianbo, et al.
Publicado: (2022)

Activated mTOR signaling pathway in myofibers with inherited metabolic defect might be an evidence for mTOR inhibition therapies
por: Lyu, Jing-Wei, et al.
Publicado: (2019)

Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking
por: Lyu, Junfang, et al.
Publicado: (2018)

PI3K/AKT/mTOR Pathway in Angiogenesis
por: Karar, Jayashree, et al.
Publicado: (2011)

ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway
por: Zhang, Qi, et al.
Publicado: (2019)

Effects of propofol on LC3II and mTOR/p-mTOR expression during ischemia-reperfusion myocardium injury in rats with type 2 diabetes mellitus
por: Wang, Ying, et al.
Publicado: (2020)

CLIC1 Drives Angiogenesis in Hepatocellular Carcinoma by Modulating VEGFA
por: Wei, Xuyong, et al.
Publicado: (2022)

GIV•Kindlin Interaction Is Required for Kindlin-Mediated Integrin Recognition and Activation
por: Rohena, Cristina, et al.
Publicado: (2020)

Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing
por: Shen, Congcong, et al.
Publicado: (2017)

Gastric Cancer Mesenchymal Stem Cells Inhibit NK Cell Function through mTOR Signalling to Promote Tumour Growth
por: Guo, Shuwei, et al.
Publicado: (2021)

Endothelial angiogenesis is directed by RUNX1T1-regulated VEGFA, BMP4 and TGF-β2 expression
por: Liao, Ko-Hsun, et al.
Publicado: (2017)

Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway
por: Wu, Tao, et al.
Publicado: (2015)

Circular RNA circ_0020710 drives tumor progression and immune evasion by regulating the miR-370-3p/CXCL12 axis in melanoma
por: Wei, Chuan-Yuan, et al.
Publicado: (2020)

Mechanism of integrin activation by talin and its cooperation with kindlin
por: Lu, Fan, et al.
Publicado: (2022)

MACC1 promotes angiogenesis in cholangiocarcinoma by upregulating VEGFA
por: Peng, Tao, et al.
Publicado: (2019)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis
por: Farhan, Maikel A., et al.
Publicado: (2015)

STAT3 and mTOR: co-operating to drive HIF and angiogenesis
por: Dodd, Kayleigh M., et al.
Publicado: (2015)

mTOR signalling pathway in stem cell bioactivities and angiogenesis potential
por: Lotfimehr, Hamid, et al.
Publicado: (2023)

Kindlin-2 regulates the differentiation of 3T3-L1 preadipocytes: implications for wound healing
por: Pan, Yuyan, et al.
Publicado: (2021)

Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis
por: Yin, Geng, et al.
Publicado: (2017)

Elevated TRIP13 drives the AKT/mTOR pathway to induce the progression of hepatocellular carcinoma via interacting with ACTN4
por: Zhu, Meng-Xuan, et al.
Publicado: (2019)

Nanosecond Pulsed Electric Fields Enhance the Anti-tumour Effects of the mTOR Inhibitor Everolimus against Melanoma
por: Dai, Jie, et al.
Publicado: (2017)

Targeting Angiogenesis by Blocking the ATM–SerRS–VEGFA Pathway for UV-Induced Skin Photodamage and Melanoma Growth
por: Song, Yadong, et al.
Publicado: (2019)

miRNA-205-5p functions as a tumor suppressor by negatively regulating VEGFA and PI3K/Akt/mTOR signaling in renal carcinoma cells
por: Huang, Jianjun, et al.
Publicado: (2019)

Activation of the mTOR signaling pathway is required for asthma onset
por: Zhang, Yanli, et al.
Publicado: (2017)

Phylogenetic Analysis of Kindlins Suggests Subfunctionalization of an Ancestral Unduplicated Kindlin into Three Paralogs in Vertebrates
por: Khan, Ammad Aslam, et al.
Publicado: (2011)

Correction to: Elevated TRIP13 drives the AKT/mTOR pathway to induce the progression of hepatocellular carcinoma via interacting with ACTN4
por: Zhu, Meng-Xuan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ejn3m2mmsl4vlu6nnck52rebp9