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LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice
Background: There is an increasing concern about age-related frailty because of the growing number of elderly people in the general population. The Longevity-Associated Variant (LAV) of the human BPIFB4 gene was found to correct endothelial dysfunction, one of the mechanisms underlying frailty, in a...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738439/ https://www.ncbi.nlm.nih.gov/pubmed/31461407 http://dx.doi.org/10.18632/aging.102209 |