LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice

Background: There is an increasing concern about age-related frailty because of the growing number of elderly people in the general population. The Longevity-Associated Variant (LAV) of the human BPIFB4 gene was found to correct endothelial dysfunction, one of the mechanisms underlying frailty, in a...

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Detalles Bibliográficos
Autores principales: Malavolta, Marco, Dato, Serena, Villa, Francesco, Rango, Francesco De, Iannone, Francesca, Ferrario, Anna, Maciag, Anna, Ciaglia, Elena, D'amato, Antonio, Carrizzo, Albino, Basso, Andrea, Orlando, Fiorenza, Provinciali, Mauro, Madeddu, Paolo, Passarino, Giuseppe, Vecchione, Carmine, Rose, Giuseppina, Puca, Annibale A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738439/
https://www.ncbi.nlm.nih.gov/pubmed/31461407
http://dx.doi.org/10.18632/aging.102209

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