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Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that ranks as the fourth most common cause of death in developed countries. In our study, genes differentially expressed between AD and healthy individuals were identified and used to construct protein-protein interaction (PPI) netw...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738443/ https://www.ncbi.nlm.nih.gov/pubmed/31422384 http://dx.doi.org/10.18632/aging.102169 |
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author | Zou, Cuihua Wang, Jie Huang, Xiaohua Jian, Chongdong Zou, Donghua Li, Xuebin |
author_facet | Zou, Cuihua Wang, Jie Huang, Xiaohua Jian, Chongdong Zou, Donghua Li, Xuebin |
author_sort | Zou, Cuihua |
collection | PubMed |
description | Alzheimer’s disease (AD) is a progressive neurodegenerative disease that ranks as the fourth most common cause of death in developed countries. In our study, genes differentially expressed between AD and healthy individuals were identified and used to construct protein-protein interaction (PPI) networks. The AD-related PPI network was used to identify functional modules, and enrichment analysis showed that they were significantly involved in “Alzheimer’s disease”, “apoptosis”, and related pathways. We predicted non-coding RNAs and transcription factors that may regulate the functional modules. The expression of hub genes and transcription factors was validated in an independent data set. The results in this study provide several candidates for further research on mechanisms of AD pathogenesis. |
format | Online Article Text |
id | pubmed-6738443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-67384432019-09-16 Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease Zou, Cuihua Wang, Jie Huang, Xiaohua Jian, Chongdong Zou, Donghua Li, Xuebin Aging (Albany NY) Research Paper Alzheimer’s disease (AD) is a progressive neurodegenerative disease that ranks as the fourth most common cause of death in developed countries. In our study, genes differentially expressed between AD and healthy individuals were identified and used to construct protein-protein interaction (PPI) networks. The AD-related PPI network was used to identify functional modules, and enrichment analysis showed that they were significantly involved in “Alzheimer’s disease”, “apoptosis”, and related pathways. We predicted non-coding RNAs and transcription factors that may regulate the functional modules. The expression of hub genes and transcription factors was validated in an independent data set. The results in this study provide several candidates for further research on mechanisms of AD pathogenesis. Impact Journals 2019-08-16 /pmc/articles/PMC6738443/ /pubmed/31422384 http://dx.doi.org/10.18632/aging.102169 Text en Copyright © 2019 Zou et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 3.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Zou, Cuihua Wang, Jie Huang, Xiaohua Jian, Chongdong Zou, Donghua Li, Xuebin Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease |
title | Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease |
title_full | Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease |
title_fullStr | Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease |
title_full_unstemmed | Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease |
title_short | Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease |
title_sort | analysis of transcription factor- and ncrna-mediated potential pathogenic gene modules in alzheimer’s disease |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738443/ https://www.ncbi.nlm.nih.gov/pubmed/31422384 http://dx.doi.org/10.18632/aging.102169 |
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