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Clinical significance of serum MicroRNA-203 in patients with acute myeloid leukemia
This study aimed to detect serum miR-203 expression levels in AML and explore its potential clinical significance. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was performed to measure the serum miR-203 levels in 134 patients with AML and 70 healthy controls. The results de...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738448/ https://www.ncbi.nlm.nih.gov/pubmed/31411110 http://dx.doi.org/10.1080/21655979.2019.1652490 |
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author | Guo, Yingmeng |
author_facet | Guo, Yingmeng |
author_sort | Guo, Yingmeng |
collection | PubMed |
description | This study aimed to detect serum miR-203 expression levels in AML and explore its potential clinical significance. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was performed to measure the serum miR-203 levels in 134 patients with AML and 70 healthy controls. The results demonstrated that serum miR-203 expression was significantly reduced in AML patients compared with healthy controls. Receiver operating characteristic curve (ROC) analysis revealed miR-203 could distinguish AML cases from normal controls. Low serum miR-203 levels were associated with worse clinical features, as well as poorer overall survival and relapse free survival of AML patients. Moreover, multivariate analysis confirmed low serum miR-203 expression to be an independent unfavorable prognostic predictor for AML. The bioinformatics analysis showed that the downstream genes and pathways of miR-203 was closely associated with tumorigenesis. Downregulation of miR-203 in AML cell lines upregulated the expression levels of oncogenic promoters such as CREB1, SRC and HDAC1. Thus, these findings demonstrated that serum miR-203 might be a promising biomarker for the diagnosis and prognosis of AML. |
format | Online Article Text |
id | pubmed-6738448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-67384482020-08-14 Clinical significance of serum MicroRNA-203 in patients with acute myeloid leukemia Guo, Yingmeng Bioengineered Research Paper This study aimed to detect serum miR-203 expression levels in AML and explore its potential clinical significance. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was performed to measure the serum miR-203 levels in 134 patients with AML and 70 healthy controls. The results demonstrated that serum miR-203 expression was significantly reduced in AML patients compared with healthy controls. Receiver operating characteristic curve (ROC) analysis revealed miR-203 could distinguish AML cases from normal controls. Low serum miR-203 levels were associated with worse clinical features, as well as poorer overall survival and relapse free survival of AML patients. Moreover, multivariate analysis confirmed low serum miR-203 expression to be an independent unfavorable prognostic predictor for AML. The bioinformatics analysis showed that the downstream genes and pathways of miR-203 was closely associated with tumorigenesis. Downregulation of miR-203 in AML cell lines upregulated the expression levels of oncogenic promoters such as CREB1, SRC and HDAC1. Thus, these findings demonstrated that serum miR-203 might be a promising biomarker for the diagnosis and prognosis of AML. Taylor & Francis 2019-08-14 /pmc/articles/PMC6738448/ /pubmed/31411110 http://dx.doi.org/10.1080/21655979.2019.1652490 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Guo, Yingmeng Clinical significance of serum MicroRNA-203 in patients with acute myeloid leukemia |
title | Clinical significance of serum MicroRNA-203 in patients with acute myeloid leukemia |
title_full | Clinical significance of serum MicroRNA-203 in patients with acute myeloid leukemia |
title_fullStr | Clinical significance of serum MicroRNA-203 in patients with acute myeloid leukemia |
title_full_unstemmed | Clinical significance of serum MicroRNA-203 in patients with acute myeloid leukemia |
title_short | Clinical significance of serum MicroRNA-203 in patients with acute myeloid leukemia |
title_sort | clinical significance of serum microrna-203 in patients with acute myeloid leukemia |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738448/ https://www.ncbi.nlm.nih.gov/pubmed/31411110 http://dx.doi.org/10.1080/21655979.2019.1652490 |
work_keys_str_mv | AT guoyingmeng clinicalsignificanceofserummicrorna203inpatientswithacutemyeloidleukemia |