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Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity

ASB20123, a C-type natriuretic peptide/ghrelin chimeric peptide, was designed as a novel peptide and demonstrated full agonistic activity for natriuretic-peptide receptor B and a significantly longer half-life in plasma compared with the native peptide. We researched the toxicological profile of ASB...

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Detalles Bibliográficos
Autores principales:	Yotsumoto, Takafumi, Morozumi, Naomi, Nakamura, Ryuichi, Jindo, Toshimasa, Furuya, Mayumi, Abe, Yasuyuki, Nishimura, Tomonari, Maeda, Hiroaki, Ogasawara, Hiroyuki, Minamitake, Yoshiharu, Kangawa, Kenji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738601/ https://www.ncbi.nlm.nih.gov/pubmed/31509532 http://dx.doi.org/10.1371/journal.pone.0218229

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