Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts

Pulmonary fibrosis (PF) is the result of chronic injury where fibroblasts become activated and secrete large amounts of extracellular matrix (ECM), leading to impaired fibroblasts degradation followed by stiffness and loss of lung function. Fructose-1,6-bisphosphate (FBP), an intermediate of glycoly...

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Detalles Bibliográficos
Autores principales: Dias, Henrique Bregolin, de Oliveira, Jarbas Rodrigues, Donadio, Márcio Vinícius Fagundes, Kimura, Shioko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738633/
https://www.ncbi.nlm.nih.gov/pubmed/31509566
http://dx.doi.org/10.1371/journal.pone.0222202

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