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Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women
AIM: To investigate circulating hormonal, metabolic and inflammatory biomarker profiles in obese and non-obese middle-aged women. METHODS: A total of 110 women, aged 40–60 years, were included in this cross-sectional study. Patients were allocated, according to the occurrence of menopause and body m...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738638/ https://www.ncbi.nlm.nih.gov/pubmed/31509577 http://dx.doi.org/10.1371/journal.pone.0222239 |
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author | Galvão-Moreira, Leonardo Victor Nascimento, Anna Cyntia Brandão D'Albuquerque, Izabella Mikaella Souza Campos Sousa, Marcus Antonio Silva Brito, Haissa Oliveira Nascimento, Maria do Desterro Soares Brandão da Costa Chein, Maria Bethânia Brito, Luciane Maria Oliveira |
author_facet | Galvão-Moreira, Leonardo Victor Nascimento, Anna Cyntia Brandão D'Albuquerque, Izabella Mikaella Souza Campos Sousa, Marcus Antonio Silva Brito, Haissa Oliveira Nascimento, Maria do Desterro Soares Brandão da Costa Chein, Maria Bethânia Brito, Luciane Maria Oliveira |
author_sort | Galvão-Moreira, Leonardo Victor |
collection | PubMed |
description | AIM: To investigate circulating hormonal, metabolic and inflammatory biomarker profiles in obese and non-obese middle-aged women. METHODS: A total of 110 women, aged 40–60 years, were included in this cross-sectional study. Patients were allocated, according to the occurrence of menopause and body mass index (BMI), into four groups: PM0 (premenopausal non-obese), PM1 (premenopausal obese), M0 (postmenopausal non-obese), and M1 (postmenopausal obese). Serum levels of gonadotropins, sex hormones, lipid markers, leptin, hs-CRP and interleukin-6 were obtained using either colorimetric or immunoenzymatic assays. Univariate and correlation analyses were performed among all clinical and laboratorial parameters. Principal component analysis was used to characterize subsets of biomarkers, which had their discriminatory capacity tested using discriminant function analysis. RESULTS: Levels of gonadotropins and female sex hormones were similar between PM0 and PM1 and between M0 and M1 (p > 0.05), all of them varied between PM0 and M0 (p < 0.05), but only estradiol was significantly altered in the comparison between PM1 and M1 (p = 0.027). Regarding metabolic markers, leptin was lower in PM0 than in M0 (p = 0.010) and higher in M1 than in M0 (p = 0.046). In premenopausal women, BMI correlated only to leptin, while it correlated to several other markers in postmenopausal women. A combination of FSH and leptin serum levels significantly discriminated the four groups (Wilks’s lambda < 0.001, in canonical functions 1 and 2). CONCLUSION: A combined analysis of hormonal biomarkers may potentially distinguish obese from non-obese women with distinct menopause status. Further research is thus required to clarify the clinical significance of such findings. |
format | Online Article Text |
id | pubmed-6738638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67386382019-09-20 Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women Galvão-Moreira, Leonardo Victor Nascimento, Anna Cyntia Brandão D'Albuquerque, Izabella Mikaella Souza Campos Sousa, Marcus Antonio Silva Brito, Haissa Oliveira Nascimento, Maria do Desterro Soares Brandão da Costa Chein, Maria Bethânia Brito, Luciane Maria Oliveira PLoS One Research Article AIM: To investigate circulating hormonal, metabolic and inflammatory biomarker profiles in obese and non-obese middle-aged women. METHODS: A total of 110 women, aged 40–60 years, were included in this cross-sectional study. Patients were allocated, according to the occurrence of menopause and body mass index (BMI), into four groups: PM0 (premenopausal non-obese), PM1 (premenopausal obese), M0 (postmenopausal non-obese), and M1 (postmenopausal obese). Serum levels of gonadotropins, sex hormones, lipid markers, leptin, hs-CRP and interleukin-6 were obtained using either colorimetric or immunoenzymatic assays. Univariate and correlation analyses were performed among all clinical and laboratorial parameters. Principal component analysis was used to characterize subsets of biomarkers, which had their discriminatory capacity tested using discriminant function analysis. RESULTS: Levels of gonadotropins and female sex hormones were similar between PM0 and PM1 and between M0 and M1 (p > 0.05), all of them varied between PM0 and M0 (p < 0.05), but only estradiol was significantly altered in the comparison between PM1 and M1 (p = 0.027). Regarding metabolic markers, leptin was lower in PM0 than in M0 (p = 0.010) and higher in M1 than in M0 (p = 0.046). In premenopausal women, BMI correlated only to leptin, while it correlated to several other markers in postmenopausal women. A combination of FSH and leptin serum levels significantly discriminated the four groups (Wilks’s lambda < 0.001, in canonical functions 1 and 2). CONCLUSION: A combined analysis of hormonal biomarkers may potentially distinguish obese from non-obese women with distinct menopause status. Further research is thus required to clarify the clinical significance of such findings. Public Library of Science 2019-09-11 /pmc/articles/PMC6738638/ /pubmed/31509577 http://dx.doi.org/10.1371/journal.pone.0222239 Text en © 2019 Galvão-Moreira et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Galvão-Moreira, Leonardo Victor Nascimento, Anna Cyntia Brandão D'Albuquerque, Izabella Mikaella Souza Campos Sousa, Marcus Antonio Silva Brito, Haissa Oliveira Nascimento, Maria do Desterro Soares Brandão da Costa Chein, Maria Bethânia Brito, Luciane Maria Oliveira Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women |
title | Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women |
title_full | Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women |
title_fullStr | Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women |
title_full_unstemmed | Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women |
title_short | Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women |
title_sort | hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese brazilian middle-aged women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738638/ https://www.ncbi.nlm.nih.gov/pubmed/31509577 http://dx.doi.org/10.1371/journal.pone.0222239 |
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