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Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study
OBJECTIVES: Upper body fat has been associated with an unfavourable cardiometabolic risk. We aimed to investigate the associations between mid-upper arm circumference (MUAC), a novel indicator of upper body fat, and a wide spectrum of cardiometabolic risk profiles in Chinese population. DESIGN AND S...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738736/ https://www.ncbi.nlm.nih.gov/pubmed/31501106 http://dx.doi.org/10.1136/bmjopen-2019-028904 |
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author | Hou, Yanan Jia, Xu Xuan, Liping Zhu, Wen Deng, Chanjuan Wang, Long Zhao, Zhiyun Li, Mian Lu, Jieli Xu, Yu Chen, Yuhong Wang, Weiqing Bi, Yufang Xu, Min Wang, Tiange |
author_facet | Hou, Yanan Jia, Xu Xuan, Liping Zhu, Wen Deng, Chanjuan Wang, Long Zhao, Zhiyun Li, Mian Lu, Jieli Xu, Yu Chen, Yuhong Wang, Weiqing Bi, Yufang Xu, Min Wang, Tiange |
author_sort | Hou, Yanan |
collection | PubMed |
description | OBJECTIVES: Upper body fat has been associated with an unfavourable cardiometabolic risk. We aimed to investigate the associations between mid-upper arm circumference (MUAC), a novel indicator of upper body fat, and a wide spectrum of cardiometabolic risk profiles in Chinese population. DESIGN AND SETTING: Cross-sectional analyses were performed using data from a well-defined community in 2014, Shanghai, China. PARTICIPANTS: A total of 6287 Chinese adults (2310 men and 3977 women) aged 40 years or older. OUTCOME MEASURES: Multivariable logistic regression model was used to examine the associations of MUAC with cardiometabolic disorders including central obesity, diabetes, hypertension, hypertriglyceridaemia, low high-density lipoprotein (HDL) cholesterol and subclinical atherosclerosis. RESULTS: In the overall participants, after multivariable adjustment, each 1 SD (3.13 cm) increment in MUAC was positively associated with central obesity (OR 2.05; 95% CI 1.85 to 2.28), hypertension (OR 1.10; 95% CI 1.03 to 1.19) and low HDL cholesterol (OR 1.10; 95% CI 1.01 to 1.22). Multivariable-adjusted ORs for subclinical atherosclerosis were gradually increased across increasing quartiles of MUAC with the lowest quartile as reference (quartile 2: OR 1.31; 95% CI 1.09 to 1.58; quartile 3: OR 1.33; 95% CI 1.10 to 1.62; quartile 4: OR 1.45; 95% CI 1.16 to 1.80; p for trend=0.005). Similar but more prominent associations were observed among women than men. In addition, MUAC was significantly interacted with diabetes (p for interaction=0.04) and insulin resistance (p for interaction=0.01) on subclinical atherosclerosis. CONCLUSION: A greater MUAC was positively associated with higher risks of several cardiometabolic disorders and subclinical atherosclerosis in Chinese adults. |
format | Online Article Text |
id | pubmed-6738736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-67387362019-09-25 Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study Hou, Yanan Jia, Xu Xuan, Liping Zhu, Wen Deng, Chanjuan Wang, Long Zhao, Zhiyun Li, Mian Lu, Jieli Xu, Yu Chen, Yuhong Wang, Weiqing Bi, Yufang Xu, Min Wang, Tiange BMJ Open Epidemiology OBJECTIVES: Upper body fat has been associated with an unfavourable cardiometabolic risk. We aimed to investigate the associations between mid-upper arm circumference (MUAC), a novel indicator of upper body fat, and a wide spectrum of cardiometabolic risk profiles in Chinese population. DESIGN AND SETTING: Cross-sectional analyses were performed using data from a well-defined community in 2014, Shanghai, China. PARTICIPANTS: A total of 6287 Chinese adults (2310 men and 3977 women) aged 40 years or older. OUTCOME MEASURES: Multivariable logistic regression model was used to examine the associations of MUAC with cardiometabolic disorders including central obesity, diabetes, hypertension, hypertriglyceridaemia, low high-density lipoprotein (HDL) cholesterol and subclinical atherosclerosis. RESULTS: In the overall participants, after multivariable adjustment, each 1 SD (3.13 cm) increment in MUAC was positively associated with central obesity (OR 2.05; 95% CI 1.85 to 2.28), hypertension (OR 1.10; 95% CI 1.03 to 1.19) and low HDL cholesterol (OR 1.10; 95% CI 1.01 to 1.22). Multivariable-adjusted ORs for subclinical atherosclerosis were gradually increased across increasing quartiles of MUAC with the lowest quartile as reference (quartile 2: OR 1.31; 95% CI 1.09 to 1.58; quartile 3: OR 1.33; 95% CI 1.10 to 1.62; quartile 4: OR 1.45; 95% CI 1.16 to 1.80; p for trend=0.005). Similar but more prominent associations were observed among women than men. In addition, MUAC was significantly interacted with diabetes (p for interaction=0.04) and insulin resistance (p for interaction=0.01) on subclinical atherosclerosis. CONCLUSION: A greater MUAC was positively associated with higher risks of several cardiometabolic disorders and subclinical atherosclerosis in Chinese adults. BMJ Publishing Group 2019-09-08 /pmc/articles/PMC6738736/ /pubmed/31501106 http://dx.doi.org/10.1136/bmjopen-2019-028904 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Epidemiology Hou, Yanan Jia, Xu Xuan, Liping Zhu, Wen Deng, Chanjuan Wang, Long Zhao, Zhiyun Li, Mian Lu, Jieli Xu, Yu Chen, Yuhong Wang, Weiqing Bi, Yufang Xu, Min Wang, Tiange Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study |
title | Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study |
title_full | Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study |
title_fullStr | Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study |
title_full_unstemmed | Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study |
title_short | Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study |
title_sort | association between mid-upper arm circumference and cardiometabolic risk in chinese population: a cross-sectional study |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738736/ https://www.ncbi.nlm.nih.gov/pubmed/31501106 http://dx.doi.org/10.1136/bmjopen-2019-028904 |
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