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Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report

RATIONALE: Active tuberculosis constitutes a relevant risk for kidney transplant recipients. In contrast to immunocompetent hosts, kidney transplant recipients often show atypical presentation and course of the disease impeding diagnosis. Especially extrapulmonary or disseminated infection is more f...

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Autores principales: Schmidt-Lauber, Christian, Jacobi, Johannes, Polifka, Iris, Hilgers, Karl F., Wiesener, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738975/
https://www.ncbi.nlm.nih.gov/pubmed/31490381
http://dx.doi.org/10.1097/MD.0000000000016995
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author Schmidt-Lauber, Christian
Jacobi, Johannes
Polifka, Iris
Hilgers, Karl F.
Wiesener, Michael S.
author_facet Schmidt-Lauber, Christian
Jacobi, Johannes
Polifka, Iris
Hilgers, Karl F.
Wiesener, Michael S.
author_sort Schmidt-Lauber, Christian
collection PubMed
description RATIONALE: Active tuberculosis constitutes a relevant risk for kidney transplant recipients. In contrast to immunocompetent hosts, kidney transplant recipients often show atypical presentation and course of the disease impeding diagnosis. Especially extrapulmonary or disseminated infection is more frequent and can resemble malignant processes. However, reactivation of tuberculosis mostly develops within the early post-transplant course, whereas malignancies are predominantly long-term complications. We report a case of disseminated abdominal tuberculosis developing 10 years after kidney transplantation and review the underlying literature. PATIENT CONCERNS AND DIAGNOSES: A 51-year-old lady presented with epigastric pain, diarrhea, weight loss and night sweats 10 years after deceased-donor kidney transplantation. An epigastric as well as multiple peritoneal masses were found suspicious of a cancer of unknown primary. Colonoscopy revealed a colon tumor with the biopsy showing no dysplasia but histiocytic and granulomatous infiltration with acid-fast bacilli. Mycobacterium tuberculosis was detected in the biopsy and stool and disseminated abdominal tuberculosi was diagnosed. INTERVENTIONS AND OUTCOMES: With anti-tuberculosis therapy, the masses regressed, and all cultures became sterile, sparing graft function. LESSONS: This case emphasizes how variable and unspecific the presentation of tuberculosis in kidney transplant recipients may be and that tuberculosis constitutes a relevant risk also in the long-term post-transplant course.
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spelling pubmed-67389752019-10-02 Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report Schmidt-Lauber, Christian Jacobi, Johannes Polifka, Iris Hilgers, Karl F. Wiesener, Michael S. Medicine (Baltimore) 5200 RATIONALE: Active tuberculosis constitutes a relevant risk for kidney transplant recipients. In contrast to immunocompetent hosts, kidney transplant recipients often show atypical presentation and course of the disease impeding diagnosis. Especially extrapulmonary or disseminated infection is more frequent and can resemble malignant processes. However, reactivation of tuberculosis mostly develops within the early post-transplant course, whereas malignancies are predominantly long-term complications. We report a case of disseminated abdominal tuberculosis developing 10 years after kidney transplantation and review the underlying literature. PATIENT CONCERNS AND DIAGNOSES: A 51-year-old lady presented with epigastric pain, diarrhea, weight loss and night sweats 10 years after deceased-donor kidney transplantation. An epigastric as well as multiple peritoneal masses were found suspicious of a cancer of unknown primary. Colonoscopy revealed a colon tumor with the biopsy showing no dysplasia but histiocytic and granulomatous infiltration with acid-fast bacilli. Mycobacterium tuberculosis was detected in the biopsy and stool and disseminated abdominal tuberculosi was diagnosed. INTERVENTIONS AND OUTCOMES: With anti-tuberculosis therapy, the masses regressed, and all cultures became sterile, sparing graft function. LESSONS: This case emphasizes how variable and unspecific the presentation of tuberculosis in kidney transplant recipients may be and that tuberculosis constitutes a relevant risk also in the long-term post-transplant course. Wolters Kluwer Health 2019-09-06 /pmc/articles/PMC6738975/ /pubmed/31490381 http://dx.doi.org/10.1097/MD.0000000000016995 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5200
Schmidt-Lauber, Christian
Jacobi, Johannes
Polifka, Iris
Hilgers, Karl F.
Wiesener, Michael S.
Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report
title Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report
title_full Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report
title_fullStr Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report
title_full_unstemmed Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report
title_short Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report
title_sort suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: a case report
topic 5200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738975/
https://www.ncbi.nlm.nih.gov/pubmed/31490381
http://dx.doi.org/10.1097/MD.0000000000016995
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