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Orbital neuroblastoma metastasis: A case report and literature review
RATIONALE: Neuroblastoma is one of the most common tumors found in children, and mostly arises in the adrenal gland and paravertebral regions. Orbital neuroblastoma metastasis is relatively rare, and is associated with poor prognosis. Since the symptoms and signs of orbital neuroblastoma are not spe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739015/ https://www.ncbi.nlm.nih.gov/pubmed/31490393 http://dx.doi.org/10.1097/MD.0000000000017038 |
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author | Yang, Wan-Ju Zhou, Yuan-Yuan Zhao, Fang Mei, Zhong-Ming Li, Shuang Xiang, Yi |
author_facet | Yang, Wan-Ju Zhou, Yuan-Yuan Zhao, Fang Mei, Zhong-Ming Li, Shuang Xiang, Yi |
author_sort | Yang, Wan-Ju |
collection | PubMed |
description | RATIONALE: Neuroblastoma is one of the most common tumors found in children, and mostly arises in the adrenal gland and paravertebral regions. Orbital neuroblastoma metastasis is relatively rare, and is associated with poor prognosis. Since the symptoms and signs of orbital neuroblastoma are not specific, its diagnosis remains challenging. PATIENT CONCERNS: A 3-year-old girl presented with periorbital ecchymoses (raccoon eyes) and proptosis for 40 days. DIAGNOSES: Abdominal magnetic resonance imaging (MRI) and sonography analysis revealed a large mass in the left adrenal gland (primary tumor). The computed tomography and MRI further revealed multiple soft tissue masses in the skull and both orbits with erosion of the adjacent bones (the metastasis). The histological analysis of the tumor removed from the right orbit confirmed the diagnosis of neuroblastoma. INTERVENTIONS: The mass on the right face was surgically removed. OUTCOMES: The patient exhibited no deteriorative signs at the 6-month follow-up. LESSONS: Clinical manifestations, such as periorbital ecchymoses and proptosis, in combination with radiological analysis and histological findings, are important for the diagnosis of orbital neuroblastoma metastasis. |
format | Online Article Text |
id | pubmed-6739015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-67390152019-10-02 Orbital neuroblastoma metastasis: A case report and literature review Yang, Wan-Ju Zhou, Yuan-Yuan Zhao, Fang Mei, Zhong-Ming Li, Shuang Xiang, Yi Medicine (Baltimore) 5800 RATIONALE: Neuroblastoma is one of the most common tumors found in children, and mostly arises in the adrenal gland and paravertebral regions. Orbital neuroblastoma metastasis is relatively rare, and is associated with poor prognosis. Since the symptoms and signs of orbital neuroblastoma are not specific, its diagnosis remains challenging. PATIENT CONCERNS: A 3-year-old girl presented with periorbital ecchymoses (raccoon eyes) and proptosis for 40 days. DIAGNOSES: Abdominal magnetic resonance imaging (MRI) and sonography analysis revealed a large mass in the left adrenal gland (primary tumor). The computed tomography and MRI further revealed multiple soft tissue masses in the skull and both orbits with erosion of the adjacent bones (the metastasis). The histological analysis of the tumor removed from the right orbit confirmed the diagnosis of neuroblastoma. INTERVENTIONS: The mass on the right face was surgically removed. OUTCOMES: The patient exhibited no deteriorative signs at the 6-month follow-up. LESSONS: Clinical manifestations, such as periorbital ecchymoses and proptosis, in combination with radiological analysis and histological findings, are important for the diagnosis of orbital neuroblastoma metastasis. Wolters Kluwer Health 2019-09-06 /pmc/articles/PMC6739015/ /pubmed/31490393 http://dx.doi.org/10.1097/MD.0000000000017038 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5800 Yang, Wan-Ju Zhou, Yuan-Yuan Zhao, Fang Mei, Zhong-Ming Li, Shuang Xiang, Yi Orbital neuroblastoma metastasis: A case report and literature review |
title | Orbital neuroblastoma metastasis: A case report and literature review |
title_full | Orbital neuroblastoma metastasis: A case report and literature review |
title_fullStr | Orbital neuroblastoma metastasis: A case report and literature review |
title_full_unstemmed | Orbital neuroblastoma metastasis: A case report and literature review |
title_short | Orbital neuroblastoma metastasis: A case report and literature review |
title_sort | orbital neuroblastoma metastasis: a case report and literature review |
topic | 5800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739015/ https://www.ncbi.nlm.nih.gov/pubmed/31490393 http://dx.doi.org/10.1097/MD.0000000000017038 |
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