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A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

Facioscapulohumeral muscular dystrophy (FSHD) results from mutations causing overexpression of the transcription factor, DUX4, which interacts with the histone acetyltransferases, EP300 and CBP. We describe the activity of a new spirocyclic EP300/CBP inhibitor, iP300w, which inhibits the cytotoxicit...

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Detalles Bibliográficos
Autores principales:	Bosnakovski, Darko, da Silva, Meiricris T., Sunny, Sithara T., Ener, Elizabeth T., Toso, Erik A., Yuan, Ce, Cui, Ziyou, Walters, Michael A., Jadhav, Ajit, Kyba, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739093/ https://www.ncbi.nlm.nih.gov/pubmed/31535023 http://dx.doi.org/10.1126/sciadv.aaw7781

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