Response to Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.

Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammali...

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Detalles Bibliográficos
Autores principales: Nakatsuji, Teruaki, Fenical, William, Gallo, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Technical Comments
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739111/
https://www.ncbi.nlm.nih.gov/pubmed/31535030
http://dx.doi.org/10.1126/sciadv.aay5611
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author Nakatsuji, Teruaki
Fenical, William
Gallo, Richard L.
author_facet Nakatsuji, Teruaki
Fenical, William
Gallo, Richard L.
author_sort Nakatsuji, Teruaki
collection PubMed
description Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. We are pleased to be able to illuminate the weaknesses in their technical comment. The totality of current results continues to support our original conclusion that a strain of the common human commensal skin bacterium, Staphylococcus epidermidis, produces 6-HAP that can inhibit tumor growth.
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spelling pubmed-67391112019-09-18 Response to Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al. Nakatsuji, Teruaki Fenical, William Gallo, Richard L. Sci Adv Technical Comments Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. We are pleased to be able to illuminate the weaknesses in their technical comment. The totality of current results continues to support our original conclusion that a strain of the common human commensal skin bacterium, Staphylococcus epidermidis, produces 6-HAP that can inhibit tumor growth. American Association for the Advancement of Science 2019-09-11 /pmc/articles/PMC6739111/ /pubmed/31535030 http://dx.doi.org/10.1126/sciadv.aay5611 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Technical Comments
Nakatsuji, Teruaki
Fenical, William
Gallo, Richard L.
Response to Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.
title Response to Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.
title_full Response to Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.
title_fullStr Response to Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.
title_full_unstemmed Response to Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.
title_short Response to Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.
title_sort response to comment on “a commensal strain of staphylococcus epidermidis protects against skin neoplasia” by nakatsuji et al.
topic Technical Comments
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739111/
https://www.ncbi.nlm.nih.gov/pubmed/31535030
http://dx.doi.org/10.1126/sciadv.aay5611
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