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Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56

The inhibitory receptors PD-1, Tim-3, and Lag-3 are highly expressed on tumor-infiltrating lymphocytes and compromise their antitumor activity. For efficient cancer immunotherapy, it is important to prevent chimeric antigen receptor T (CAR-T)-cell exhaustion. Here we downregulate these three checkpo...

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Detalles Bibliográficos
Autores principales:	Zou, Fan, Lu, Lijuan, Liu, Jun, Xia, Baijin, Zhang, Wanying, Hu, Qifei, Liu, Weiwei, Zhang, Yiwen, Lin, Yingtong, Jing, Shuliang, Huang, Mei, Huang, Bifen, Liu, Bingfeng, Zhang, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739330/ https://www.ncbi.nlm.nih.gov/pubmed/31511513 http://dx.doi.org/10.1038/s41467-019-11893-4

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