Cargando…

Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56

The inhibitory receptors PD-1, Tim-3, and Lag-3 are highly expressed on tumor-infiltrating lymphocytes and compromise their antitumor activity. For efficient cancer immunotherapy, it is important to prevent chimeric antigen receptor T (CAR-T)-cell exhaustion. Here we downregulate these three checkpo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, Fan, Lu, Lijuan, Liu, Jun, Xia, Baijin, Zhang, Wanying, Hu, Qifei, Liu, Weiwei, Zhang, Yiwen, Lin, Yingtong, Jing, Shuliang, Huang, Mei, Huang, Bifen, Liu, Bingfeng, Zhang, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739330/ https://www.ncbi.nlm.nih.gov/pubmed/31511513 http://dx.doi.org/10.1038/s41467-019-11893-4

Ejemplares similares

Enhancement of CAR‐T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins
por: Qiao, Yidan, et al.
Publicado: (2023)

Lovastatin Inhibits HIV-1-Induced MHC-I Downregulation by Targeting Nef–AP-1 Complex Formation: A New Strategy to Boost Immune Eradication of HIV-1 Infected Cells
por: Liu, Bingfeng, et al.
Publicado: (2019)

Nanobody-derived bispecific CAR-T cell therapy enhances the anti-tumor efficacy of T cell lymphoma treatment
por: Xia, Baijin, et al.
Publicado: (2023)

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection
por: Zhang, Wanying, et al.
Publicado: (2022)

The CD39(+) HBV surface protein-targeted CAR-T and personalized tumor-reactive CD8(+) T cells exhibit potent anti-HCC activity
por: Zou, Fan, et al.
Publicado: (2021)

Engineering CAR-T cells
por: Zhang, Cheng, et al.
Publicado: (2017)

Recent advances in CAR-T cell engineering
por: Huang, Ruihao, et al.
Publicado: (2020)

Engineering switchable and programmable universal CARs for CAR T therapy
por: Liu, Delong, et al.
Publicado: (2019)

Dual Negativity of CD56 and CD117 Links to Unfavorable Cytogenetic Abnormalities and Predicts Poor Prognosis in Multiple Myeloma
por: Zheng, Dong, et al.
Publicado: (2022)

Engineering CAR T cells for enhanced efficacy and safety
por: Wu, Yiqian, et al.
Publicado: (2022)

Engineered IL-7 Receptor Enhances the Therapeutic Effect of AXL-CAR-T Cells on Triple-Negative Breast Cancer
por: Zhao, Zhenhui, et al.
Publicado: (2020)

Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy
por: Bangayan, Nathanael J., et al.
Publicado: (2023)

The roles of NOP56 in cancer and SCA36
por: Zhao, Shimin, et al.
Publicado: (2023)

MicroRNA profiling of CD3(+)CD56(+) cytokine-induced killer cells
por: Wang, Wenju, et al.
Publicado: (2015)

Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration
por: Luo, Baohong, et al.
Publicado: (2020)

Nano-Optogenetic Engineering of CAR T-cells for Precision Immunotherapy with Enhanced Safety
por: Nguyen, Nhung Thi, et al.
Publicado: (2021)

CAR-T Regulatory (CAR-Treg) Cells: Engineering and Applications
por: Arjomandnejad, Motahareh, et al.
Publicado: (2022)

Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L
por: Yu, Fei, et al.
Publicado: (2022)

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι
por: Zhang, Yiwen, et al.
Publicado: (2021)

Triple concerto in C major, opus 56 : for violin, cello, piano and 2nd piano (reduction of the orchestra) [Conciertos]
por: Beethoven, Ludwig van, 1770-1827
Publicado: (1987)

Alterations in the CD56(−) and CD56(+) T Cell Subsets during COVID-19
por: Vavilova, Julia D., et al.
Publicado: (2023)

Inhibition of CXorf56 promotes PARP inhibitor-induced cytotoxicity in triple-negative breast cancer
por: Zhu, Ying, et al.
Publicado: (2023)

Expression of CD22 in Triple-Negative Breast Cancer: A Novel Prognostic Biomarker and Potential Target for CAR Therapy
por: Zaib, Tahir, et al.
Publicado: (2023)

Strategies to enhance CAR-T persistence
por: Liu, Yue, et al.
Publicado: (2022)

CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19(+)HLA-C1(−) Malignant B Cells While Sparing CD19(+)HLA-C1(+) Healthy B Cells
por: Tao, Lei, et al.
Publicado: (2020)

Assessment and predictive ability of the absolute neutrophil count in peripheral blood for in vivo CAR T cells expansion and CRS
por: Zhang, Man, et al.
Publicado: (2023)

The Function of CD3(+)CD56(+) NKT-Like Cells in HIV-Infected Individuals
por: Jiang, Yongjun, et al.
Publicado: (2014)

Engineering light-controllable CAR T cells for cancer immunotherapy
por: Huang, Ziliang, et al.
Publicado: (2020)

Experimental Study and Mechanism Analysis of the Flow Boiling and Heat Transfer Characteristics in Microchannels with Different Surface Wettability
por: Zhou, Shengnan, et al.
Publicado: (2021)

Expansion of CD56(dim)CD16(neg) NK Cell Subset and Increased Inhibitory KIRs in Hospitalized COVID-19 Patients
por: Casado, José L., et al.
Publicado: (2021)

A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross‐Protection Activity against Multiple SARS‐CoV‐2 Sublineages
por: Zhang, Xiantao, et al.
Publicado: (2023)

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function
por: Salzer, Benjamin, et al.
Publicado: (2020)

Anti-CAR-engineered T cells for epitope-based elimination of autologous CAR T cells
por: Koristka, Stefanie, et al.
Publicado: (2019)

CD56(+) B-cell Neurolymphomatosis in a Cat
por: Hsueh, C.-S., et al.
Publicado: (2019)

Engineering a Reliable and Convenient SARS-CoV-2 Replicon System for Analysis of Viral RNA Synthesis and Screening of Antiviral Inhibitors
por: Luo, Yuewen, et al.
Publicado: (2021)

The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56(bright) NK cells
por: Ziegler, Annerose E., et al.
Publicado: (2023)

Intercellular Adhesion Molecule-1 as Target for CAR-T-Cell Therapy of Triple-Negative Breast Cancer
por: Wei, Heng, et al.
Publicado: (2020)

To be or not to be: the role of CD56 in multiple myeloma
por: Cottini, Francesca, et al.
Publicado: (2023)

Analysis of the Characteristics of TIGIT-Expressing CD3(−)CD56(+)NK Cells in Controlling Different Stages of HIV-1 Infection
por: Zhang, Xin, et al.
Publicado: (2021)

Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions
por: Meng, Xianhui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_t8c4pobpia57h23ps1qd56bae0