In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene

Many neuropsychiatric risk genes contribute to epigenetic regulation but little is known about specific chromatin-associated mechanisms governing the formation of neuronal connectivity. Here we show that transcallosal connectivity is critically dependent on C11orf46, a nuclear protein encoded in the...

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Detalles Bibliográficos
Autores principales: Peter, Cyril J., Saito, Atsushi, Hasegawa, Yuto, Tanaka, Yuya, Nagpal, Mohika, Perez, Gabriel, Alway, Emily, Espeso-Gil, Sergio, Fayyad, Tariq, Ratner, Chana, Dincer, Aslihan, Gupta, Achla, Devi, Lakshmi, Pappas, John G., Lalonde, François M., Butman, John A., Han, Joan C., Akbarian, Schahram, Kamiya, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739341/
https://www.ncbi.nlm.nih.gov/pubmed/31511512
http://dx.doi.org/10.1038/s41467-019-12013-y

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