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SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity

Lipid metabolism that correlates tightly to the glucose metabolic regulation in malignant cells includes hepatocellular carcinoma (HCC) cells. The transcription factor Sterol Regulatory Element Binding Protein 1 (SREBP-1), a regulator of fatty acid synthesis, has been shown to pivotally regulate the...

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Detalles Bibliográficos
Autores principales:	Yin, Fan, Feng, Fan, Wang, Lei, Wang, Xiaoning, Li, Zongwei, Cao, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739379/ https://www.ncbi.nlm.nih.gov/pubmed/31511501 http://dx.doi.org/10.1038/s41419-019-1884-7

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