DMBT1 inhibition of Pseudomonas aeruginosa twitching motility involves its N-glycosylation and cannot be conferred by the Scavenger Receptor Cysteine-Rich bacteria-binding peptide domain

The scavenging capacity of glycoprotein DMBT1 helps defend mucosal epithelia against microbes. DMBT1 binding to multiple bacterial species involves its conserved Scavenger Receptor Cysteine-Rich (SRCR) domains, localized to a 16-mer consensus sequence peptide, SRCRP2. Previously, we showed that DMBT...

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Detalles Bibliográficos
Autores principales: Li, Jianfang, Wan, Stephanie J., Metruccio, Matteo M. E., Ma, Sophia, Nazmi, Kamran, Bikker, Floris J., Evans, David J., Fleiszig, Suzanne M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739395/
https://www.ncbi.nlm.nih.gov/pubmed/31511582
http://dx.doi.org/10.1038/s41598-019-49543-w

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