Identification of Benzyloxy Carbonimidoyl Dicyanide Derivatives as Novel Type III Secretion System Inhibitors via High-Throughput Screening

The type III secretion system (T3SS) in many Gram-negative bacterial pathogens is regarded as the most critical virulence determinant and an attractive target for novel anti-virulence drugs. In this study, we constructed a T3SS secretion reporter containing the β-lactamase gene fused with a signal p...

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Detalles Bibliográficos
Autores principales: Ma, Yi-Nan, Chen, Liang, Si, Nai-Guo, Jiang, Wen-Jun, Zhou, Zhi-Gang, Liu, Jun-Li, Zhang, Li-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Plant Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739442/
https://www.ncbi.nlm.nih.gov/pubmed/31543889
http://dx.doi.org/10.3389/fpls.2019.01059

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