Intestinal Gel-Forming Mucins Polymerize by Disulfide-Mediated Dimerization of D3 Domains

The mucin 2 glycoprotein assembles into a complex hydrogel that protects intestinal epithelia and houses the gut microbiome. A major step in mucin 2 assembly is further multimerization of preformed mucin dimers, thought to produce a honeycomb-like arrangement upon hydrogel expansion. Important open...

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Detalles Bibliográficos
Autores principales: Javitt, Gabriel, Calvo, María Luisa Gómez, Albert, Lis, Reznik, Nava, Ilani, Tal, Diskin, Ron, Fass, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739602/
https://www.ncbi.nlm.nih.gov/pubmed/31310764
http://dx.doi.org/10.1016/j.jmb.2019.07.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739602/
https://www.ncbi.nlm.nih.gov/pubmed/31310764
http://dx.doi.org/10.1016/j.jmb.2019.07.018

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