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Intestinal Gel-Forming Mucins Polymerize by Disulfide-Mediated Dimerization of D3 Domains
The mucin 2 glycoprotein assembles into a complex hydrogel that protects intestinal epithelia and houses the gut microbiome. A major step in mucin 2 assembly is further multimerization of preformed mucin dimers, thought to produce a honeycomb-like arrangement upon hydrogel expansion. Important open...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739602/ https://www.ncbi.nlm.nih.gov/pubmed/31310764 http://dx.doi.org/10.1016/j.jmb.2019.07.018 |