Cargando…
Off-Pathway Assembly: A Broad-Spectrum Mechanism of Action for Drugs That Undermine Controlled HIV-1 Viral Capsid Formation
[Image: see text] The early and late stages of human immunodeficiency virus (HIV) replication are orchestrated by the capsid (CA) protein, which self-assembles into a conical protein shell during viral maturation. Small molecule drugs known as capsid inhibitors (CIs) impede the highly regulated acti...
Autores principales: | Pak, Alexander J., Grime, John M. A., Yu, Alvin, Voth, Gregory A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2019
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739737/ https://www.ncbi.nlm.nih.gov/pubmed/31244184 http://dx.doi.org/10.1021/jacs.9b01413 |
Ejemplares similares
-
Critical mechanistic features of HIV-1 viral capsid assembly
por: Gupta, Manish, et al.
Publicado: (2023) -
TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
por: Yu, Alvin, et al.
Publicado: (2020) -
Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly
por: Grime, John M. A., et al.
Publicado: (2016) -
A Broad-Spectrum Antiviral Molecule, Protoporphyrin IX, Acts as a Moderator of HIV-1 Capsid Assembly by Targeting the Capsid Hexamer
por: Zhang, Da-Wei, et al.
Publicado: (2022) -
Strain and rupture of HIV-1 capsids during uncoating
por: Yu, Alvin, et al.
Publicado: (2022)