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Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses

OBJECTIVES: This study aimed to identify the possible effects of Myc and 8q24 polymorphisms on bleeding complications in patients who maintained international normalized ratio (INR) of 2.0-3.0 with warfarin therapy after cardiac valve replacement. METHODS: Twenty-five single nucleotide polymorphisms...

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Autores principales: Yee, Jeong, Kim, Woorim, Chang, Byung Chul, Chung, Jee Eun, Lee, Kyung Eun, Gwak, Hye Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739803/
https://www.ncbi.nlm.nih.gov/pubmed/31772606
http://dx.doi.org/10.1155/2019/1813747
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author Yee, Jeong
Kim, Woorim
Chang, Byung Chul
Chung, Jee Eun
Lee, Kyung Eun
Gwak, Hye Sun
author_facet Yee, Jeong
Kim, Woorim
Chang, Byung Chul
Chung, Jee Eun
Lee, Kyung Eun
Gwak, Hye Sun
author_sort Yee, Jeong
collection PubMed
description OBJECTIVES: This study aimed to identify the possible effects of Myc and 8q24 polymorphisms on bleeding complications in patients who maintained international normalized ratio (INR) of 2.0-3.0 with warfarin therapy after cardiac valve replacement. METHODS: Twenty-five single nucleotide polymorphisms were analyzed, including VKORC1, CYP2C9, Myc, and 8q24. Univariate and multivariate analyses were conducted to evaluate the associations between genetic polymorphisms and bleeding complications. Attributable risk and the number needed to genotype (NNG) were also calculated to evaluate the potential clinical value of genotyping. RESULTS: We included 142 patients, among whom 21 experienced bleeding complications. Multivariate models showed that patients carrying the CC genotype of rs6983561 and the A allele of rs13281615 at 8q24 had 27.6- and 10.0-fold higher bleeding complications, compared with patients with the A allele and the GG genotype, respectively. For rs6983561, the attributable risk and NNG were 96.4% and 36.8, respectively, whereas, for rs13281615, the attributable risk and NNG were 90.0% and 8.3, respectively. Atrial fibrillation was associated with a 5.5-fold increased risk of bleeding complications. The AUROC value was 0.761 (95% CI 0.659-0.863, p<0.001), and the Hosmer–Lemeshow test showed that the fitness of the multivariate analysis model was satisfactory (χ(2)=0.846; 3 degrees of freedom; p=0.838). CONCLUSIONS: Bleeding complications during warfarin therapy were associated with 8q24 polymorphisms and atrial fibrillation in patients with mechanical heart valves.
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spelling pubmed-67398032019-09-17 Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses Yee, Jeong Kim, Woorim Chang, Byung Chul Chung, Jee Eun Lee, Kyung Eun Gwak, Hye Sun Cardiovasc Ther Research Article OBJECTIVES: This study aimed to identify the possible effects of Myc and 8q24 polymorphisms on bleeding complications in patients who maintained international normalized ratio (INR) of 2.0-3.0 with warfarin therapy after cardiac valve replacement. METHODS: Twenty-five single nucleotide polymorphisms were analyzed, including VKORC1, CYP2C9, Myc, and 8q24. Univariate and multivariate analyses were conducted to evaluate the associations between genetic polymorphisms and bleeding complications. Attributable risk and the number needed to genotype (NNG) were also calculated to evaluate the potential clinical value of genotyping. RESULTS: We included 142 patients, among whom 21 experienced bleeding complications. Multivariate models showed that patients carrying the CC genotype of rs6983561 and the A allele of rs13281615 at 8q24 had 27.6- and 10.0-fold higher bleeding complications, compared with patients with the A allele and the GG genotype, respectively. For rs6983561, the attributable risk and NNG were 96.4% and 36.8, respectively, whereas, for rs13281615, the attributable risk and NNG were 90.0% and 8.3, respectively. Atrial fibrillation was associated with a 5.5-fold increased risk of bleeding complications. The AUROC value was 0.761 (95% CI 0.659-0.863, p<0.001), and the Hosmer–Lemeshow test showed that the fitness of the multivariate analysis model was satisfactory (χ(2)=0.846; 3 degrees of freedom; p=0.838). CONCLUSIONS: Bleeding complications during warfarin therapy were associated with 8q24 polymorphisms and atrial fibrillation in patients with mechanical heart valves. Hindawi 2019-05-08 /pmc/articles/PMC6739803/ /pubmed/31772606 http://dx.doi.org/10.1155/2019/1813747 Text en Copyright © 2019 Jeong Yee et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yee, Jeong
Kim, Woorim
Chang, Byung Chul
Chung, Jee Eun
Lee, Kyung Eun
Gwak, Hye Sun
Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses
title Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses
title_full Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses
title_fullStr Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses
title_full_unstemmed Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses
title_short Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses
title_sort effects of polymorphisms in myc-related genes on bleeding complications in patients with stable warfarin responses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739803/
https://www.ncbi.nlm.nih.gov/pubmed/31772606
http://dx.doi.org/10.1155/2019/1813747
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