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The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats

Cues in the environment can elicit complex emotional states, and thereby maladaptive behavior, as a function of their ascribed value. Here we capture individual variation in the propensity to attribute motivational value to reward-cues using the sign-tracker/goal-tracker animal model. Goal-trackers...

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Autores principales: Campus, Paolo, Covelo, Ignacio R, Kim, Youngsoo, Parsegian, Aram, Kuhn, Brittany N, Lopez, Sofia A, Neumaier, John F, Ferguson, Susan M, Solberg Woods, Leah C, Sarter, Martin, Flagel, Shelly B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739869/
https://www.ncbi.nlm.nih.gov/pubmed/31502538
http://dx.doi.org/10.7554/eLife.49041
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author Campus, Paolo
Covelo, Ignacio R
Kim, Youngsoo
Parsegian, Aram
Kuhn, Brittany N
Lopez, Sofia A
Neumaier, John F
Ferguson, Susan M
Solberg Woods, Leah C
Sarter, Martin
Flagel, Shelly B
author_facet Campus, Paolo
Covelo, Ignacio R
Kim, Youngsoo
Parsegian, Aram
Kuhn, Brittany N
Lopez, Sofia A
Neumaier, John F
Ferguson, Susan M
Solberg Woods, Leah C
Sarter, Martin
Flagel, Shelly B
author_sort Campus, Paolo
collection PubMed
description Cues in the environment can elicit complex emotional states, and thereby maladaptive behavior, as a function of their ascribed value. Here we capture individual variation in the propensity to attribute motivational value to reward-cues using the sign-tracker/goal-tracker animal model. Goal-trackers attribute predictive value to reward-cues, and sign-trackers attribute both predictive and incentive value. Using chemogenetics and microdialysis, we show that, in sign-trackers, stimulation of the neuronal pathway from the prelimbic cortex (PrL) to the paraventricular nucleus of the thalamus (PVT) decreases the incentive value of a reward-cue. In contrast, in goal-trackers, inhibition of the PrL-PVT pathway increases both the incentive value and dopamine levels in the nucleus accumbens shell. The PrL-PVT pathway, therefore, exerts top-down control over the dopamine-dependent process of incentive salience attribution. These results highlight PrL-PVT pathway as a potential target for treating psychopathologies associated with the attribution of excessive incentive value to reward-cues, including addiction.
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spelling pubmed-67398692019-09-13 The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats Campus, Paolo Covelo, Ignacio R Kim, Youngsoo Parsegian, Aram Kuhn, Brittany N Lopez, Sofia A Neumaier, John F Ferguson, Susan M Solberg Woods, Leah C Sarter, Martin Flagel, Shelly B eLife Neuroscience Cues in the environment can elicit complex emotional states, and thereby maladaptive behavior, as a function of their ascribed value. Here we capture individual variation in the propensity to attribute motivational value to reward-cues using the sign-tracker/goal-tracker animal model. Goal-trackers attribute predictive value to reward-cues, and sign-trackers attribute both predictive and incentive value. Using chemogenetics and microdialysis, we show that, in sign-trackers, stimulation of the neuronal pathway from the prelimbic cortex (PrL) to the paraventricular nucleus of the thalamus (PVT) decreases the incentive value of a reward-cue. In contrast, in goal-trackers, inhibition of the PrL-PVT pathway increases both the incentive value and dopamine levels in the nucleus accumbens shell. The PrL-PVT pathway, therefore, exerts top-down control over the dopamine-dependent process of incentive salience attribution. These results highlight PrL-PVT pathway as a potential target for treating psychopathologies associated with the attribution of excessive incentive value to reward-cues, including addiction. eLife Sciences Publications, Ltd 2019-09-10 /pmc/articles/PMC6739869/ /pubmed/31502538 http://dx.doi.org/10.7554/eLife.49041 Text en © 2019, Campus et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Campus, Paolo
Covelo, Ignacio R
Kim, Youngsoo
Parsegian, Aram
Kuhn, Brittany N
Lopez, Sofia A
Neumaier, John F
Ferguson, Susan M
Solberg Woods, Leah C
Sarter, Martin
Flagel, Shelly B
The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats
title The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats
title_full The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats
title_fullStr The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats
title_full_unstemmed The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats
title_short The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats
title_sort paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739869/
https://www.ncbi.nlm.nih.gov/pubmed/31502538
http://dx.doi.org/10.7554/eLife.49041
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