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The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats
Cues in the environment can elicit complex emotional states, and thereby maladaptive behavior, as a function of their ascribed value. Here we capture individual variation in the propensity to attribute motivational value to reward-cues using the sign-tracker/goal-tracker animal model. Goal-trackers...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739869/ https://www.ncbi.nlm.nih.gov/pubmed/31502538 http://dx.doi.org/10.7554/eLife.49041 |
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author | Campus, Paolo Covelo, Ignacio R Kim, Youngsoo Parsegian, Aram Kuhn, Brittany N Lopez, Sofia A Neumaier, John F Ferguson, Susan M Solberg Woods, Leah C Sarter, Martin Flagel, Shelly B |
author_facet | Campus, Paolo Covelo, Ignacio R Kim, Youngsoo Parsegian, Aram Kuhn, Brittany N Lopez, Sofia A Neumaier, John F Ferguson, Susan M Solberg Woods, Leah C Sarter, Martin Flagel, Shelly B |
author_sort | Campus, Paolo |
collection | PubMed |
description | Cues in the environment can elicit complex emotional states, and thereby maladaptive behavior, as a function of their ascribed value. Here we capture individual variation in the propensity to attribute motivational value to reward-cues using the sign-tracker/goal-tracker animal model. Goal-trackers attribute predictive value to reward-cues, and sign-trackers attribute both predictive and incentive value. Using chemogenetics and microdialysis, we show that, in sign-trackers, stimulation of the neuronal pathway from the prelimbic cortex (PrL) to the paraventricular nucleus of the thalamus (PVT) decreases the incentive value of a reward-cue. In contrast, in goal-trackers, inhibition of the PrL-PVT pathway increases both the incentive value and dopamine levels in the nucleus accumbens shell. The PrL-PVT pathway, therefore, exerts top-down control over the dopamine-dependent process of incentive salience attribution. These results highlight PrL-PVT pathway as a potential target for treating psychopathologies associated with the attribution of excessive incentive value to reward-cues, including addiction. |
format | Online Article Text |
id | pubmed-6739869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-67398692019-09-13 The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats Campus, Paolo Covelo, Ignacio R Kim, Youngsoo Parsegian, Aram Kuhn, Brittany N Lopez, Sofia A Neumaier, John F Ferguson, Susan M Solberg Woods, Leah C Sarter, Martin Flagel, Shelly B eLife Neuroscience Cues in the environment can elicit complex emotional states, and thereby maladaptive behavior, as a function of their ascribed value. Here we capture individual variation in the propensity to attribute motivational value to reward-cues using the sign-tracker/goal-tracker animal model. Goal-trackers attribute predictive value to reward-cues, and sign-trackers attribute both predictive and incentive value. Using chemogenetics and microdialysis, we show that, in sign-trackers, stimulation of the neuronal pathway from the prelimbic cortex (PrL) to the paraventricular nucleus of the thalamus (PVT) decreases the incentive value of a reward-cue. In contrast, in goal-trackers, inhibition of the PrL-PVT pathway increases both the incentive value and dopamine levels in the nucleus accumbens shell. The PrL-PVT pathway, therefore, exerts top-down control over the dopamine-dependent process of incentive salience attribution. These results highlight PrL-PVT pathway as a potential target for treating psychopathologies associated with the attribution of excessive incentive value to reward-cues, including addiction. eLife Sciences Publications, Ltd 2019-09-10 /pmc/articles/PMC6739869/ /pubmed/31502538 http://dx.doi.org/10.7554/eLife.49041 Text en © 2019, Campus et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Campus, Paolo Covelo, Ignacio R Kim, Youngsoo Parsegian, Aram Kuhn, Brittany N Lopez, Sofia A Neumaier, John F Ferguson, Susan M Solberg Woods, Leah C Sarter, Martin Flagel, Shelly B The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats |
title | The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats |
title_full | The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats |
title_fullStr | The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats |
title_full_unstemmed | The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats |
title_short | The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats |
title_sort | paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739869/ https://www.ncbi.nlm.nih.gov/pubmed/31502538 http://dx.doi.org/10.7554/eLife.49041 |
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