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Epigenetic silencing of a multifunctional plant stress regulator
The central regulator of the ethylene (ET) signaling pathway, which controls a plethora of developmental programs and responses to environmental cues in plants, is ETHYLENE-INSENSITIVE2 (EIN2). Here we identify a chromatin-dependent regulatory mechanism at EIN2 requiring two genes: ETHYLENE-INSENSIT...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739875/ https://www.ncbi.nlm.nih.gov/pubmed/31418686 http://dx.doi.org/10.7554/eLife.47835 |
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author | Zander, Mark Willige, Björn C He, Yupeng Nguyen, Thu A Langford, Amber E Nehring, Ramlah Howell, Elizabeth McGrath, Robert Bartlett, Anna Castanon, Rosa Nery, Joseph R Chen, Huaming Zhang, Zhuzhu Jupe, Florian Stepanova, Anna Schmitz, Robert J Lewsey, Mathew G Chory, Joanne Ecker, Joseph R |
author_facet | Zander, Mark Willige, Björn C He, Yupeng Nguyen, Thu A Langford, Amber E Nehring, Ramlah Howell, Elizabeth McGrath, Robert Bartlett, Anna Castanon, Rosa Nery, Joseph R Chen, Huaming Zhang, Zhuzhu Jupe, Florian Stepanova, Anna Schmitz, Robert J Lewsey, Mathew G Chory, Joanne Ecker, Joseph R |
author_sort | Zander, Mark |
collection | PubMed |
description | The central regulator of the ethylene (ET) signaling pathway, which controls a plethora of developmental programs and responses to environmental cues in plants, is ETHYLENE-INSENSITIVE2 (EIN2). Here we identify a chromatin-dependent regulatory mechanism at EIN2 requiring two genes: ETHYLENE-INSENSITIVE6 (EIN6), which is a H3K27me3 demethylase also known as RELATIVE OF EARLY FLOWERING6 (REF6), and EIN6 ENHANCER (EEN), the Arabidopsis homolog of the yeast INO80 chromatin remodeling complex subunit IES6 (INO EIGHTY SUBUNIT). Strikingly, EIN6 (REF6) and the INO80 complex redundantly control the level and the localization of the repressive histone modification H3K27me3 and the histone variant H2A.Z at the 5’ untranslated region (5’UTR) intron of EIN2. Concomitant loss of EIN6 (REF6) and the INO80 complex shifts the chromatin landscape at EIN2 to a repressive state causing a dramatic reduction of EIN2 expression. These results uncover a unique type of chromatin regulation which safeguards the expression of an essential multifunctional plant stress regulator. |
format | Online Article Text |
id | pubmed-6739875 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-67398752019-09-13 Epigenetic silencing of a multifunctional plant stress regulator Zander, Mark Willige, Björn C He, Yupeng Nguyen, Thu A Langford, Amber E Nehring, Ramlah Howell, Elizabeth McGrath, Robert Bartlett, Anna Castanon, Rosa Nery, Joseph R Chen, Huaming Zhang, Zhuzhu Jupe, Florian Stepanova, Anna Schmitz, Robert J Lewsey, Mathew G Chory, Joanne Ecker, Joseph R eLife Genetics and Genomics The central regulator of the ethylene (ET) signaling pathway, which controls a plethora of developmental programs and responses to environmental cues in plants, is ETHYLENE-INSENSITIVE2 (EIN2). Here we identify a chromatin-dependent regulatory mechanism at EIN2 requiring two genes: ETHYLENE-INSENSITIVE6 (EIN6), which is a H3K27me3 demethylase also known as RELATIVE OF EARLY FLOWERING6 (REF6), and EIN6 ENHANCER (EEN), the Arabidopsis homolog of the yeast INO80 chromatin remodeling complex subunit IES6 (INO EIGHTY SUBUNIT). Strikingly, EIN6 (REF6) and the INO80 complex redundantly control the level and the localization of the repressive histone modification H3K27me3 and the histone variant H2A.Z at the 5’ untranslated region (5’UTR) intron of EIN2. Concomitant loss of EIN6 (REF6) and the INO80 complex shifts the chromatin landscape at EIN2 to a repressive state causing a dramatic reduction of EIN2 expression. These results uncover a unique type of chromatin regulation which safeguards the expression of an essential multifunctional plant stress regulator. eLife Sciences Publications, Ltd 2019-08-16 /pmc/articles/PMC6739875/ /pubmed/31418686 http://dx.doi.org/10.7554/eLife.47835 Text en © 2019, Zander et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Genetics and Genomics Zander, Mark Willige, Björn C He, Yupeng Nguyen, Thu A Langford, Amber E Nehring, Ramlah Howell, Elizabeth McGrath, Robert Bartlett, Anna Castanon, Rosa Nery, Joseph R Chen, Huaming Zhang, Zhuzhu Jupe, Florian Stepanova, Anna Schmitz, Robert J Lewsey, Mathew G Chory, Joanne Ecker, Joseph R Epigenetic silencing of a multifunctional plant stress regulator |
title | Epigenetic silencing of a multifunctional plant stress regulator |
title_full | Epigenetic silencing of a multifunctional plant stress regulator |
title_fullStr | Epigenetic silencing of a multifunctional plant stress regulator |
title_full_unstemmed | Epigenetic silencing of a multifunctional plant stress regulator |
title_short | Epigenetic silencing of a multifunctional plant stress regulator |
title_sort | epigenetic silencing of a multifunctional plant stress regulator |
topic | Genetics and Genomics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739875/ https://www.ncbi.nlm.nih.gov/pubmed/31418686 http://dx.doi.org/10.7554/eLife.47835 |
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