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The Study of Release Mechanisms for Drug in Cyclodextrin Metal–Organic Frameworks

[Image: see text] γ-Cyclodextrin metal–organic frameworks (γCDMOF) recently emerged as biofriendly, highly porous, and crystalline materials with potential applications in drug delivery. However, little is known about their drug entrapment and release characteristics, which are key parameters in the...

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Autores principales: Liu, Congbiao, Guo, Tao, Li, Weimin, Jiang, Zhiteng, Chen, Min, Xu, Nongzhang, Fang, Zhongjian, Wang, Cuihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740174/
https://www.ncbi.nlm.nih.gov/pubmed/31528802
http://dx.doi.org/10.1021/acsomega.9b01634
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author Liu, Congbiao
Guo, Tao
Li, Weimin
Jiang, Zhiteng
Chen, Min
Xu, Nongzhang
Fang, Zhongjian
Wang, Cuihong
author_facet Liu, Congbiao
Guo, Tao
Li, Weimin
Jiang, Zhiteng
Chen, Min
Xu, Nongzhang
Fang, Zhongjian
Wang, Cuihong
author_sort Liu, Congbiao
collection PubMed
description [Image: see text] γ-Cyclodextrin metal–organic frameworks (γCDMOF) recently emerged as biofriendly, highly porous, and crystalline materials with potential applications in drug delivery. However, little is known about their drug entrapment and release characteristics, which are key parameters in the design of drug carriers. The macroscopic properties of a material are determined by its microstructure. Thus, the characteristics of the constitutive units of the cubic crystalline γCDMOF determine their drug loading and release behaviors. In this study, the release profile of prednisolone (PNS) form γCDMOF was predicted, and the mechanism was analyzed based on the γCDMOF molecular structure. For the first time, experimental, molecular simulation, and mathematical modeling methods were combined to gain insights into the drug distribution in cubic porous crystals of γCDMOF as well as on drug release kinetics. The predicted release profile was in good agreement with the experimental results, showing that the modeling method was reliable. The methodology developed here could provide a reference for further investigations of drug penetration and release in supramolecular systems.
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spelling pubmed-67401742019-09-16 The Study of Release Mechanisms for Drug in Cyclodextrin Metal–Organic Frameworks Liu, Congbiao Guo, Tao Li, Weimin Jiang, Zhiteng Chen, Min Xu, Nongzhang Fang, Zhongjian Wang, Cuihong ACS Omega [Image: see text] γ-Cyclodextrin metal–organic frameworks (γCDMOF) recently emerged as biofriendly, highly porous, and crystalline materials with potential applications in drug delivery. However, little is known about their drug entrapment and release characteristics, which are key parameters in the design of drug carriers. The macroscopic properties of a material are determined by its microstructure. Thus, the characteristics of the constitutive units of the cubic crystalline γCDMOF determine their drug loading and release behaviors. In this study, the release profile of prednisolone (PNS) form γCDMOF was predicted, and the mechanism was analyzed based on the γCDMOF molecular structure. For the first time, experimental, molecular simulation, and mathematical modeling methods were combined to gain insights into the drug distribution in cubic porous crystals of γCDMOF as well as on drug release kinetics. The predicted release profile was in good agreement with the experimental results, showing that the modeling method was reliable. The methodology developed here could provide a reference for further investigations of drug penetration and release in supramolecular systems. American Chemical Society 2019-08-27 /pmc/articles/PMC6740174/ /pubmed/31528802 http://dx.doi.org/10.1021/acsomega.9b01634 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Liu, Congbiao
Guo, Tao
Li, Weimin
Jiang, Zhiteng
Chen, Min
Xu, Nongzhang
Fang, Zhongjian
Wang, Cuihong
The Study of Release Mechanisms for Drug in Cyclodextrin Metal–Organic Frameworks
title The Study of Release Mechanisms for Drug in Cyclodextrin Metal–Organic Frameworks
title_full The Study of Release Mechanisms for Drug in Cyclodextrin Metal–Organic Frameworks
title_fullStr The Study of Release Mechanisms for Drug in Cyclodextrin Metal–Organic Frameworks
title_full_unstemmed The Study of Release Mechanisms for Drug in Cyclodextrin Metal–Organic Frameworks
title_short The Study of Release Mechanisms for Drug in Cyclodextrin Metal–Organic Frameworks
title_sort study of release mechanisms for drug in cyclodextrin metal–organic frameworks
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740174/
https://www.ncbi.nlm.nih.gov/pubmed/31528802
http://dx.doi.org/10.1021/acsomega.9b01634
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