Osteonecrosis of the Jaw and Concomitant Atypical Femoral Fractures with Bisphosphonates: A Comprehensive Literature Review

Bisphosphonates are the first line of treatment for osteoporosis. Complications of bisphosphonates, such as osteonecrosis of the jaw (ONJ) and atypical femoral fractures (AFF), have been reported in the medical literature. Concomitant occurrence of both of these complications is very rare. In this r...

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Autores principales: Meyyur Aravamudan, Veeraraghavan, Er, Chaozer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741378/
https://www.ncbi.nlm.nih.gov/pubmed/31523544
http://dx.doi.org/10.7759/cureus.5113
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author Meyyur Aravamudan, Veeraraghavan
Er, Chaozer
author_facet Meyyur Aravamudan, Veeraraghavan
Er, Chaozer
author_sort Meyyur Aravamudan, Veeraraghavan
collection PubMed
description Bisphosphonates are the first line of treatment for osteoporosis. Complications of bisphosphonates, such as osteonecrosis of the jaw (ONJ) and atypical femoral fractures (AFF), have been reported in the medical literature. Concomitant occurrence of both of these complications is very rare. In this review article, we will discuss the etiology, pathogenesis, and clinical studies, as well as case studies and their management per the latest clinical guidelines.
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spelling pubmed-67413782019-09-15 Osteonecrosis of the Jaw and Concomitant Atypical Femoral Fractures with Bisphosphonates: A Comprehensive Literature Review Meyyur Aravamudan, Veeraraghavan Er, Chaozer Cureus Endocrinology/Diabetes/Metabolism Bisphosphonates are the first line of treatment for osteoporosis. Complications of bisphosphonates, such as osteonecrosis of the jaw (ONJ) and atypical femoral fractures (AFF), have been reported in the medical literature. Concomitant occurrence of both of these complications is very rare. In this review article, we will discuss the etiology, pathogenesis, and clinical studies, as well as case studies and their management per the latest clinical guidelines. Cureus 2019-07-09 /pmc/articles/PMC6741378/ /pubmed/31523544 http://dx.doi.org/10.7759/cureus.5113 Text en Copyright © 2019, Meyyur Aravamudan et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Meyyur Aravamudan, Veeraraghavan
Er, Chaozer
Osteonecrosis of the Jaw and Concomitant Atypical Femoral Fractures with Bisphosphonates: A Comprehensive Literature Review
title Osteonecrosis of the Jaw and Concomitant Atypical Femoral Fractures with Bisphosphonates: A Comprehensive Literature Review
title_full Osteonecrosis of the Jaw and Concomitant Atypical Femoral Fractures with Bisphosphonates: A Comprehensive Literature Review
title_fullStr Osteonecrosis of the Jaw and Concomitant Atypical Femoral Fractures with Bisphosphonates: A Comprehensive Literature Review
title_full_unstemmed Osteonecrosis of the Jaw and Concomitant Atypical Femoral Fractures with Bisphosphonates: A Comprehensive Literature Review
title_short Osteonecrosis of the Jaw and Concomitant Atypical Femoral Fractures with Bisphosphonates: A Comprehensive Literature Review
title_sort osteonecrosis of the jaw and concomitant atypical femoral fractures with bisphosphonates: a comprehensive literature review
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741378/
https://www.ncbi.nlm.nih.gov/pubmed/31523544
http://dx.doi.org/10.7759/cureus.5113
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