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Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration

BACKGROUND: Environmental and endogenous factors under genetic predisposition are considered to initiate the human intervertebral disc (IVD) degeneration. DNA methylation is an essential mechanism to ensure cell-specific gene expression for normal development and tissue stability. Aberrant epigeneti...

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Detalles Bibliográficos
Autores principales:	Ikuno, Akihiro, Akeda, Koji, Takebayashi, Shin-ichiro, Shimaoka, Motomu, Okumura, Katsuzumi, Sudo, Akihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742346/ https://www.ncbi.nlm.nih.gov/pubmed/31513634 http://dx.doi.org/10.1371/journal.pone.0222188

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