A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene

Pancreatic adenocarcinoma (PC) is a lethal malignancy that is familial or associated with genetic syndromes in 10% of cases. Gene-based surveillance strategies for at-risk individuals may improve clinical outcomes. However, familial PC (FPC) is plagued by genetic heterogeneity and the genetic basis...

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Detalles Bibliográficos
Autores principales: Wong, Cavin, Chen, Fei, Alirezaie, Najmeh, Wang, Yifan, Cuggia, Adeline, Borgida, Ayelet, Holter, Spring, Lenko, Tatiana, Domecq, Celine, Petersen, Gloria M., Syngal, Sapna, Brand, Randall, Rustgi, Anil K., Cote, Michele L., Stoffel, Elena, Olson, Sara H., Roberts, Nicholas J., Akbari, Mohammad R., Majewski, Jacek, Klein, Alison P., Greenwood, Celia M. T., Gallinger, Steven, Zogopoulos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742418/
https://www.ncbi.nlm.nih.gov/pubmed/31469826
http://dx.doi.org/10.1371/journal.pgen.1008344

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