Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

The immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor G6b-B is critical for platelet production and activation. Loss of G6b-B results in severe macrothrombocytopenia, myelofibrosis and aberrant platelet function in mice and humans. Using a combination of immunohistochemistry,...

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Detalles Bibliográficos
Autores principales: Vögtle, Timo, Sharma, Sumana, Mori, Jun, Nagy, Zoltan, Semeniak, Daniela, Scandola, Cyril, Geer, Mitchell J, Smith, Christopher W, Lane, Jordan, Pollack, Scott, Lassila, Riitta, Jouppila, Annukka, Barr, Alastair J, Ogg, Derek J, Howard, Tina D, McMiken, Helen J, Warwicker, Juli, Geh, Catherine, Rowlinson, Rachel, Abbott, W Mark, Eckly, Anita, Schulze, Harald, Wright, Gavin J, Mazharian, Alexandra, Fütterer, Klaus, Rajesh, Sundaresan, Douglas, Michael R, Senis, Yotis A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742478/
https://www.ncbi.nlm.nih.gov/pubmed/31436532
http://dx.doi.org/10.7554/eLife.46840

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