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Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation

PURPOSE: To evaluate the clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation (NSOI). METHODS: This retrospective study evaluates 76 patients with NSOI. The patients were categorized in 9 groups according to the site o...

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Autores principales: Eshraghi, Bahram, Sonbolestan, Seyed Ali, Abtahi, Mohammad-Ali, Mirmohammadsadeghi, Arash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742620/
https://www.ncbi.nlm.nih.gov/pubmed/31528770
http://dx.doi.org/10.1016/j.joco.2019.03.004
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author Eshraghi, Bahram
Sonbolestan, Seyed Ali
Abtahi, Mohammad-Ali
Mirmohammadsadeghi, Arash
author_facet Eshraghi, Bahram
Sonbolestan, Seyed Ali
Abtahi, Mohammad-Ali
Mirmohammadsadeghi, Arash
author_sort Eshraghi, Bahram
collection PubMed
description PURPOSE: To evaluate the clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation (NSOI). METHODS: This retrospective study evaluates 76 patients with NSOI. The patients were categorized in 9 groups according to the site of involvement and histopathology results. These groups included: anterior involvement, dacryoadenitis, myositis, perineural involvement, acute fat involvement, focal mass, orbital apex involvement, diffuse sclerosing form, and multiple tissue involvement. The course of the disease was categorized as acute, subacute, or chronic. The cases with symptom duration of less than 1 week were classified as acute, 1 week to 1 month as subacute, and more than 1 month as chronic. RESULTS: 36 (47.4%) patients were males. The mean age was 41.68 ± 17.62 (6–75) years. The most common signs and symptoms were periorbital pain, periorbital edema, decreased ocular movements or diplopia, and conjunctival injection. The most common group was dacryoadenitis in 29 (38.1%) cases. The most common form of disease was the acute involvement (50% of patients). Most of the patients were treated by oral corticosteroids. Duration of follow-up was 7.17 ± 6.26 months. Recurrence occurred in 9 (11.8%) of patients during the follow-up period. CONCLUSIONS: This study presents a new categorization in which multiple tissue involvements were separated. Some of the NSOI features differ between adults and children. In most patients, treatment especially with corticosteroids, resolves the clinical findings.
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spelling pubmed-67426202019-09-16 Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation Eshraghi, Bahram Sonbolestan, Seyed Ali Abtahi, Mohammad-Ali Mirmohammadsadeghi, Arash J Curr Ophthalmol Article PURPOSE: To evaluate the clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation (NSOI). METHODS: This retrospective study evaluates 76 patients with NSOI. The patients were categorized in 9 groups according to the site of involvement and histopathology results. These groups included: anterior involvement, dacryoadenitis, myositis, perineural involvement, acute fat involvement, focal mass, orbital apex involvement, diffuse sclerosing form, and multiple tissue involvement. The course of the disease was categorized as acute, subacute, or chronic. The cases with symptom duration of less than 1 week were classified as acute, 1 week to 1 month as subacute, and more than 1 month as chronic. RESULTS: 36 (47.4%) patients were males. The mean age was 41.68 ± 17.62 (6–75) years. The most common signs and symptoms were periorbital pain, periorbital edema, decreased ocular movements or diplopia, and conjunctival injection. The most common group was dacryoadenitis in 29 (38.1%) cases. The most common form of disease was the acute involvement (50% of patients). Most of the patients were treated by oral corticosteroids. Duration of follow-up was 7.17 ± 6.26 months. Recurrence occurred in 9 (11.8%) of patients during the follow-up period. CONCLUSIONS: This study presents a new categorization in which multiple tissue involvements were separated. Some of the NSOI features differ between adults and children. In most patients, treatment especially with corticosteroids, resolves the clinical findings. Elsevier 2019-03-28 /pmc/articles/PMC6742620/ /pubmed/31528770 http://dx.doi.org/10.1016/j.joco.2019.03.004 Text en © 2019 Iranian Society of Ophthalmology. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Eshraghi, Bahram
Sonbolestan, Seyed Ali
Abtahi, Mohammad-Ali
Mirmohammadsadeghi, Arash
Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation
title Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation
title_full Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation
title_fullStr Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation
title_full_unstemmed Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation
title_short Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation
title_sort clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742620/
https://www.ncbi.nlm.nih.gov/pubmed/31528770
http://dx.doi.org/10.1016/j.joco.2019.03.004
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