GSTA4 mediates reduction of cisplatin ototoxicity in female mice

Cisplatin is one of the most widely used chemotherapeutic drugs for the treatment of cancer. Unfortunately, one of its major side effects is permanent hearing loss. Here, we show that glutathione transferase α4 (GSTA4), a member of the Phase II detoxifying enzyme superfamily, mediates reduction of c...

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Detalles Bibliográficos
Autores principales: Park, Hyo-Jin, Kim, Mi-Jung, Rothenberger, Christina, Kumar, Ashok, Sampson, Edith M., Ding, Dalian, Han, Chul, White, Karessa, Boyd, Kevin, Manohar, Senthilvelan, Kim, Yong-Hwan, Ticsa, Maria S., Gomez, Aaron S., Caicedo, Isabela, Bose, Upal, Linser, Paul J., Miyakawa, Takuya, Tanokura, Masaru, Foster, Thomas C., Salvi, Richard, Someya, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742643/
https://www.ncbi.nlm.nih.gov/pubmed/31515474
http://dx.doi.org/10.1038/s41467-019-12073-0

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