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Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors

The laterodorsal tegmentum (LDT) is associated with reward considering that it modulates VTA neuronal activity, but recent anatomical evidence shows that the LDT also directly projects to nucleus accumbens (NAc). We show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergi...

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Autores principales: Coimbra, Bárbara, Soares-Cunha, Carina, Vasconcelos, Nivaldo A P, Domingues, Ana Verónica, Borges, Sónia, Sousa, Nuno, Rodrigues, Ana João
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742663/
https://www.ncbi.nlm.nih.gov/pubmed/31515512
http://dx.doi.org/10.1038/s41467-019-11557-3
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author Coimbra, Bárbara
Soares-Cunha, Carina
Vasconcelos, Nivaldo A P
Domingues, Ana Verónica
Borges, Sónia
Sousa, Nuno
Rodrigues, Ana João
author_facet Coimbra, Bárbara
Soares-Cunha, Carina
Vasconcelos, Nivaldo A P
Domingues, Ana Verónica
Borges, Sónia
Sousa, Nuno
Rodrigues, Ana João
author_sort Coimbra, Bárbara
collection PubMed
description The laterodorsal tegmentum (LDT) is associated with reward considering that it modulates VTA neuronal activity, but recent anatomical evidence shows that the LDT also directly projects to nucleus accumbens (NAc). We show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergic and glutamatergic innervation; activation of LDT induces a predominantly excitatory response in the NAc. Non-selective optogenetic activation of LDT-NAc projections in rats enhances motivational drive and shifts preference to an otherwise equal reward; whereas inhibition of these projections induces the opposite. Activation of these projections also induces robust place preference. In mice, specific activation of LDT-NAc cholinergic inputs (but not glutamatergic or GABAergic) is sufficient to shift preference, increase motivation, and drive positive reinforcement in different behavioral paradigms. These results provide evidence that LDT-NAc projections play an important role in motivated behaviors and positive reinforcement, and that distinct neuronal populations differentially contribute for these behaviors.
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spelling pubmed-67426632019-09-16 Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors Coimbra, Bárbara Soares-Cunha, Carina Vasconcelos, Nivaldo A P Domingues, Ana Verónica Borges, Sónia Sousa, Nuno Rodrigues, Ana João Nat Commun Article The laterodorsal tegmentum (LDT) is associated with reward considering that it modulates VTA neuronal activity, but recent anatomical evidence shows that the LDT also directly projects to nucleus accumbens (NAc). We show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergic and glutamatergic innervation; activation of LDT induces a predominantly excitatory response in the NAc. Non-selective optogenetic activation of LDT-NAc projections in rats enhances motivational drive and shifts preference to an otherwise equal reward; whereas inhibition of these projections induces the opposite. Activation of these projections also induces robust place preference. In mice, specific activation of LDT-NAc cholinergic inputs (but not glutamatergic or GABAergic) is sufficient to shift preference, increase motivation, and drive positive reinforcement in different behavioral paradigms. These results provide evidence that LDT-NAc projections play an important role in motivated behaviors and positive reinforcement, and that distinct neuronal populations differentially contribute for these behaviors. Nature Publishing Group UK 2019-09-12 /pmc/articles/PMC6742663/ /pubmed/31515512 http://dx.doi.org/10.1038/s41467-019-11557-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Coimbra, Bárbara
Soares-Cunha, Carina
Vasconcelos, Nivaldo A P
Domingues, Ana Verónica
Borges, Sónia
Sousa, Nuno
Rodrigues, Ana João
Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors
title Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors
title_full Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors
title_fullStr Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors
title_full_unstemmed Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors
title_short Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors
title_sort role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742663/
https://www.ncbi.nlm.nih.gov/pubmed/31515512
http://dx.doi.org/10.1038/s41467-019-11557-3
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