Cargando…

Effect of early-stage autophagy inhibition in BRAF(V600E) autophagy-dependent brain tumor cells

Autophagy is a multistage process. Progress within the field has led to the development of agents targeting both early (initiation) and late (fusion) stages of this process. The specific stage of autophagy targeted may influence cancer treatment outcomes. We have previously shown that central nervou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zahedi, Shadi, Fitzwalter, Brent E., Morin, Andrew, Grob, Sydney, Desmarais, Michele, Nellan, Anandani, Green, Adam L., Vibhakar, Rajeev, Hankinson, Todd C., Foreman, Nicholas K., Mulcahy Levy, Jean M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742667/ https://www.ncbi.nlm.nih.gov/pubmed/31515514 http://dx.doi.org/10.1038/s41419-019-1880-y

Ejemplares similares

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
por: Mulcahy Levy, Jean M, et al.
Publicado: (2017)

RARE-18. NF1-MUTATED TUMORS EXHIBIT INCREASED SENSITIVITY TO AUTOPHAGY INHIBITION ALONE AND IN COMBINATION WITH MEK INHIBITION
por: Baird-Daniel, Eliza, et al.
Publicado: (2021)

LGG-34. CLINICAL AND MOLECULAR CHARACTERIZATION OF A MULTI-INSTITUTIONAL COHORT OF PEDIATRIC SPINAL CORD LOW-GRADE GLIOMAS
por: Grob, Sydney, et al.
Publicado: (2020)

LGG-48. PROLIFIC GROWTH OF BRAF V600E MUTANT PILOCYTIC ASTROCYTOMA WHILE ON KETOGENIC DIET: CASE REPORT
por: Batchelder, Patti, et al.
Publicado: (2020)

Using BRAF(V600E) as a marker of autophagy dependence in pediatric brain tumors
por: Levy, Jean M Mulcahy, et al.
Publicado: (2014)

Clinical and molecular characterization of a multi-institutional cohort of pediatric spinal cord low-grade gliomas
por: Grob, Sydney T, et al.
Publicado: (2020)

MODL-01. SAFETY IN CONCOMITANT USE OF MEK AND BRAF INHIBITORS WITH BEVACIZUMAB
por: Winzent, Shelby, et al.
Publicado: (2020)

Autophagy: When to strike?
por: Zahedi, Shadi, et al.
Publicado: (2020)

LGG-55. Autophagy sensitizes CNS tumors to targeted therapy by lowering their apoptotic threshold
por: Crespo, Michele, et al.
Publicado: (2022)

ATRT-20. CDK7 INHIBITION IN AT/RT
por: Morin, Andrew, et al.
Publicado: (2020)

QOL-36. USE OF CANNABINOIDS IN THE PEDIATRIC CENTRAL NERVOUS SYSTEM TUMOR POPULATION
por: Dorris, Kathleen, et al.
Publicado: (2020)

ATRT-24. CDK7 Inhibition in AT/RT
por: Morin, Andrew, et al.
Publicado: (2022)

Proteasome inhibition as a therapeutic approach in atypical teratoid/rhabdoid tumors
por: Morin, Andrew, et al.
Publicado: (2020)

Autophagy inhibition improves anti-cancer drugs via FOXO3a activation
por: Fitzwalter, Brent E., et al.
Publicado: (2018)

ATRT-24. CELL SURFACE PROTEOME ANALYSIS OF ATRT IDENTIFIES TARGETS FOR IMMUNOTHERAPY
por: Cole, Allison, et al.
Publicado: (2020)

The role of BRAF V600 mutation in melanoma
por: Ascierto, Paolo A, et al.
Publicado: (2012)

New insights into intranuclear inclusions in thyroid carcinoma: Association with autophagy and with BRAF(V600E) mutation
por: Schwertheim, Suzan, et al.
Publicado: (2019)

Ouabain and chloroquine trigger senolysis of BRAF‐V600E‐induced senescent cells by targeting autophagy
por: L’Hôte, Valentin, et al.
Publicado: (2021)

(V600E)BRAF Inhibition Induces Cytoprotective Autophagy through AMPK in Thyroid Cancer Cells
por: Jiménez-Mora, Eva, et al.
Publicado: (2021)

Targeting IL-6 Is a Potential Treatment for Primary Cystic Craniopharyngioma
por: Grob, Sydney, et al.
Publicado: (2019)

EMBR-27. NEOPLASTIC AND IMMUNE SINGLE CELL TRANSCRIPTOMICS DEFINE SUBGROUP-SPECIFIC INTRA-TUMORAL HETEROGENEITY OF CHILDHOOD MEDULLOBLASTOMA
por: Donson, Andrew, et al.
Publicado: (2021)

Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF(V600E)-Mutant Human Glioma
por: Schreck, Karisa C., et al.
Publicado: (2021)

IMMU-20. EVALUATION OF CAR T CELLS IN EPENDYMOMA
por: Nellan, Anandani, et al.
Publicado: (2020)

BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells
por: Goulielmaki, Maria, et al.
Publicado: (2016)

BRAF(V600E) inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells
por: Sueda, Toshinori, et al.
Publicado: (2016)

Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib
por: Goodall, Megan L, et al.
Publicado: (2014)

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition
por: Xue, Gongda, et al.
Publicado: (2017)

HGG-18. SINGLE CELL RNA-SEQ ANALYSIS OF PEDIATRIC HIGH-GRADE GLIOMA PATIENT SAMPLES IDENTIFIES COMMON GLIAL AND IMMUNE CELL TYPES THAT HELP TO EXPLAIN HETEROGENEITY AND TUMORIGENESIS
por: DeSisto, John, et al.
Publicado: (2023)

Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells
por: Nellan, Anandani, et al.
Publicado: (2018)

Autophagy Inhibition in BRAF-Driven Cancers
por: Foth, Mona, et al.
Publicado: (2021)

BRAF(V600E) protein expression and outcome from BRAF inhibitor treatment in BRAF(V600E) metastatic melanoma
por: Wilmott, J S, et al.
Publicado: (2013)

BRAF V600E Inhibitor (Vemurafenib) for BRAF V600E Mutated Low Grade Gliomas
por: Del Bufalo, Francesca, et al.
Publicado: (2018)

LGG-22. CHARACTERIZATION OF THE TUMOR MICROENVIRONMENT IN PEDIATRIC LOW-GRADE GLIOMA
por: Zahedi, Shadi, et al.
Publicado: (2023)

The Cytoprotective Role of Autophagy in Response to BRAF-Targeted Therapies
por: Elshazly, Ahmed M., et al.
Publicado: (2023)

RONC-05. Peri-transplant Radiation Therapy for Young Children Treated with High-Dose Chemotherapy for Primary Brain Tumors
por: Milgrom, Sarah, et al.
Publicado: (2022)

Differential Sensitivity of Wild-Type and BRAF-Mutated Cells to Combined BRAF and Autophagy Inhibition
por: Yeom, Hojin, et al.
Publicado: (2021)

Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy
por: Robinson, Giles W, et al.
Publicado: (2014)

BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma
por: Mehnert, Janice M., et al.
Publicado: (2022)

BRAF Inhibition in BRAF(V600)-Mutant Gliomas: Results From the VE-BASKET Study
por: Kaley, Thomas, et al.
Publicado: (2018)

Acquired resistance to BRAF inhibition in BRAF(V600E) mutant gliomas
por: Yao, Tsun-Wen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_r31bbp4q5rfnlgsct1kfuc8e8t