Cargando…

Chapter 12: Decompressive Craniectomy: Long Term Outcome and Ethical Considerations

Decompressive craniectomy (DC) for the treatment of severe traumatic brain injury (TBI) has been established to decrease mortality. Despite the conclusion of the two largest randomized clinical trials associating the effectiveness of decompressive craniectomy vs. medical management for patients with...

Descripción completa

Detalles Bibliográficos
Autores principales: Kwan, Kevin, Schneider, Julia, Ullman, Jamie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742692/
https://www.ncbi.nlm.nih.gov/pubmed/31555193
http://dx.doi.org/10.3389/fneur.2019.00876
_version_ 1783451147635261440
author Kwan, Kevin
Schneider, Julia
Ullman, Jamie S.
author_facet Kwan, Kevin
Schneider, Julia
Ullman, Jamie S.
author_sort Kwan, Kevin
collection PubMed
description Decompressive craniectomy (DC) for the treatment of severe traumatic brain injury (TBI) has been established to decrease mortality. Despite the conclusion of the two largest randomized clinical trials associating the effectiveness of decompressive craniectomy vs. medical management for patients with traumatic brain injury (TBI), there is still clinical equipoise concerning the usefulness of DC in the management of refractory intracranial hypertension. Primary outcome data from these studies reveal either potential harm or that decreased mortality only leads to an upsurge in survivors with severe neurologic incapacity. In this chapter, we seek to review the results of the most recent clinical trials, highlight the prevailing controversies, and offer potential solutions to address this dilemma.
format Online
Article
Text
id pubmed-6742692
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-67426922019-09-25 Chapter 12: Decompressive Craniectomy: Long Term Outcome and Ethical Considerations Kwan, Kevin Schneider, Julia Ullman, Jamie S. Front Neurol Neurology Decompressive craniectomy (DC) for the treatment of severe traumatic brain injury (TBI) has been established to decrease mortality. Despite the conclusion of the two largest randomized clinical trials associating the effectiveness of decompressive craniectomy vs. medical management for patients with traumatic brain injury (TBI), there is still clinical equipoise concerning the usefulness of DC in the management of refractory intracranial hypertension. Primary outcome data from these studies reveal either potential harm or that decreased mortality only leads to an upsurge in survivors with severe neurologic incapacity. In this chapter, we seek to review the results of the most recent clinical trials, highlight the prevailing controversies, and offer potential solutions to address this dilemma. Frontiers Media S.A. 2019-09-06 /pmc/articles/PMC6742692/ /pubmed/31555193 http://dx.doi.org/10.3389/fneur.2019.00876 Text en Copyright © 2019 Kwan, Schneider and Ullman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Kwan, Kevin
Schneider, Julia
Ullman, Jamie S.
Chapter 12: Decompressive Craniectomy: Long Term Outcome and Ethical Considerations
title Chapter 12: Decompressive Craniectomy: Long Term Outcome and Ethical Considerations
title_full Chapter 12: Decompressive Craniectomy: Long Term Outcome and Ethical Considerations
title_fullStr Chapter 12: Decompressive Craniectomy: Long Term Outcome and Ethical Considerations
title_full_unstemmed Chapter 12: Decompressive Craniectomy: Long Term Outcome and Ethical Considerations
title_short Chapter 12: Decompressive Craniectomy: Long Term Outcome and Ethical Considerations
title_sort chapter 12: decompressive craniectomy: long term outcome and ethical considerations
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742692/
https://www.ncbi.nlm.nih.gov/pubmed/31555193
http://dx.doi.org/10.3389/fneur.2019.00876
work_keys_str_mv AT kwankevin chapter12decompressivecraniectomylongtermoutcomeandethicalconsiderations
AT schneiderjulia chapter12decompressivecraniectomylongtermoutcomeandethicalconsiderations
AT ullmanjamies chapter12decompressivecraniectomylongtermoutcomeandethicalconsiderations