Controlling the Phenotype of Tumor-Infiltrating Macrophages via the PHD-HIF Axis Inhibits Tumor Growth in a Mouse Model

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The tumor microenvironment (TME) polarizes tumor-infiltrating macrophages toward tumor support. Macrophage-abundant tumors are highly malignant and are the cause of poor prognosis and therapeutic resistance. In this study, we show that the prolyl hydroxylase (PHD) inhibitor FG-4592 (FG) inhibits tum...

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Detalles Bibliográficos
Autores principales: Nishide, Shunji, Matsunaga, Shinji, Shiota, Masayuki, Yamaguchi, Takehiro, Kitajima, Shojiro, Maekawa, Yoichi, Takeda, Norihiko, Tomura, Michio, Uchida, Junji, Miura, Katsuyuki, Nakatani, Tatsuya, Tomita, Shuhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742914/
https://www.ncbi.nlm.nih.gov/pubmed/31518902
http://dx.doi.org/10.1016/j.isci.2019.08.033

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