Models of Variability and Circadian Rhythm in Heart Rate, Blood Pressure, and QT Interval for Healthy Subjects Who Received Placebo in Phase I Trials

This work characterized the time‐course, circadian rhythm, and inherent variability in key cardiovascular variables (heart rate, corrected QT interval, and systolic and diastolic blood pressure) that are routinely collected as part of safety monitoring in phase I trials. Longitudinal data from 1,035...

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Detalles Bibliográficos
Autores principales: Minocha, Mukul, Li, Hong, Chiu, Yi‐Lin, Carter, David, Othman, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742942/
https://www.ncbi.nlm.nih.gov/pubmed/31021448
http://dx.doi.org/10.1111/cts.12640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742942/
https://www.ncbi.nlm.nih.gov/pubmed/31021448
http://dx.doi.org/10.1111/cts.12640

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