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Heart defibrillation: relationship between pacing threshold and defibrillation probability

BACKGROUND: Considering the clinical importance of the ventricular fibrillation and that the most used therapy to reverse it has a critical side effect on the cardiac tissue, it is desirable to optimize defibrillation parameters to increase its efficiency. In this study, we investigated the influenc...

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Autores principales: Antoneli, Priscila C., Goulart, Jair T., Bonilha, Isabella, de Carvalho, Daniela D., de Oliveira, Pedro X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743100/
https://www.ncbi.nlm.nih.gov/pubmed/31519192
http://dx.doi.org/10.1186/s12938-019-0715-5
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author Antoneli, Priscila C.
Goulart, Jair T.
Bonilha, Isabella
de Carvalho, Daniela D.
de Oliveira, Pedro X.
author_facet Antoneli, Priscila C.
Goulart, Jair T.
Bonilha, Isabella
de Carvalho, Daniela D.
de Oliveira, Pedro X.
author_sort Antoneli, Priscila C.
collection PubMed
description BACKGROUND: Considering the clinical importance of the ventricular fibrillation and that the most used therapy to reverse it has a critical side effect on the cardiac tissue, it is desirable to optimize defibrillation parameters to increase its efficiency. In this study, we investigated the influence of stimuli duration on the relationship between pacing threshold and defibrillation probability. RESULTS: We found out that 0.5-ms-long pulses had a lower ratio of defibrillation probability to the pacing threshold, although the higher the pulse duration the lower is the electric field intensity required to defibrillate the hearts. CONCLUSION: The appropriate choice of defibrillatory shock parameters is able to increase the efficiency of the defibrillation improving the survival chances after the occurrence of a severe arrhythmia. The relationship between pulse duration and the probability of reversal of fibrillation shows that this parameter cannot be underestimated in defibrillator design since different pulse durations have different levels of safety.
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spelling pubmed-67431002019-09-16 Heart defibrillation: relationship between pacing threshold and defibrillation probability Antoneli, Priscila C. Goulart, Jair T. Bonilha, Isabella de Carvalho, Daniela D. de Oliveira, Pedro X. Biomed Eng Online Research BACKGROUND: Considering the clinical importance of the ventricular fibrillation and that the most used therapy to reverse it has a critical side effect on the cardiac tissue, it is desirable to optimize defibrillation parameters to increase its efficiency. In this study, we investigated the influence of stimuli duration on the relationship between pacing threshold and defibrillation probability. RESULTS: We found out that 0.5-ms-long pulses had a lower ratio of defibrillation probability to the pacing threshold, although the higher the pulse duration the lower is the electric field intensity required to defibrillate the hearts. CONCLUSION: The appropriate choice of defibrillatory shock parameters is able to increase the efficiency of the defibrillation improving the survival chances after the occurrence of a severe arrhythmia. The relationship between pulse duration and the probability of reversal of fibrillation shows that this parameter cannot be underestimated in defibrillator design since different pulse durations have different levels of safety. BioMed Central 2019-09-13 /pmc/articles/PMC6743100/ /pubmed/31519192 http://dx.doi.org/10.1186/s12938-019-0715-5 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Antoneli, Priscila C.
Goulart, Jair T.
Bonilha, Isabella
de Carvalho, Daniela D.
de Oliveira, Pedro X.
Heart defibrillation: relationship between pacing threshold and defibrillation probability
title Heart defibrillation: relationship between pacing threshold and defibrillation probability
title_full Heart defibrillation: relationship between pacing threshold and defibrillation probability
title_fullStr Heart defibrillation: relationship between pacing threshold and defibrillation probability
title_full_unstemmed Heart defibrillation: relationship between pacing threshold and defibrillation probability
title_short Heart defibrillation: relationship between pacing threshold and defibrillation probability
title_sort heart defibrillation: relationship between pacing threshold and defibrillation probability
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743100/
https://www.ncbi.nlm.nih.gov/pubmed/31519192
http://dx.doi.org/10.1186/s12938-019-0715-5
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