Cargando…

Therapeutic efficacy of a novel humanized antibody-drug conjugate recognizing plexin-semaphorin-integrin domain in the RON receptor for targeted cancer therapy

BACKGROUND: Antibody-drug conjugates (ADCs) targeting the RON receptor, a tumorigenic factor contributing to cancer malignancy, has been considered as a novel strategy for cancer therapy. Here we describe a humanized antibody recognizing the RON plexin-semaphorin-integrin (PSI) domain with increased...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tong, Xiang-Min, Feng, Liang, Suthe, Sreedhar Reddy, Weng, Tian-Hao, Hu, Chen-Yu, Liu, Yi-Zhi, Wu, Zhi-Gang, Wang, Ming-Hai, Yao, Hang-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743155/ https://www.ncbi.nlm.nih.gov/pubmed/31519211 http://dx.doi.org/10.1186/s40425-019-0732-8

Ejemplares similares

Targeting RON receptor tyrosine kinase for treatment of advanced solid cancers: antibody–drug conjugates as lead drug candidates for clinical trials
por: Yao, Hang-Ping, et al.
Publicado: (2020)

Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy
por: Yao, Hang-Ping, et al.
Publicado: (2019)

Correction to: Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy
por: Yao, Hang-Ping, et al.
Publicado: (2019)

Structure of the Plexin Ectodomain Bound by Semaphorin-Mimicking Antibodies
por: Suzuki, Kei, et al.
Publicado: (2016)

Evolution and Diversity of Semaphorins and Plexins in Choanoflagellates
por: Junqueira Alves, Chrystian, et al.
Publicado: (2021)

Structural basis of semaphorin‐plexin cis interaction
por: Rozbesky, Daniel, et al.
Publicado: (2020)

Nanobody inhibitors of Plexin-B1 identify allostery in plexin–semaphorin interactions and signaling
por: Cowan, Richard, et al.
Publicado: (2023)

Current drug design to target the Semaphorin/Neuropilin/Plexin complexes
por: Meyer, Lionel A. T., et al.
Publicado: (2016)

Retrograde Semaphorin-Plexin Signaling Drives Homeostatic Synaptic Plasticity
por: Orr, Brian O., et al.
Publicado: (2017)

Origin and evolution of plexins, semaphorins, and Met receptor tyrosine kinases
por: Junqueira Alves, Chrystian, et al.
Publicado: (2019)

Adult expression of Semaphorins and Plexins is essential for motor neuron survival
por: Vaikakkara Chithran, Aarya, et al.
Publicado: (2023)

Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase
por: Ma, Qi, et al.
Publicado: (2010)

Plexin-B2 and Semaphorins Do Not Drive Rhabdomyosarcoma Proliferation or Migration
por: Karki, Anju, et al.
Publicado: (2022)

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex
por: Janssen, Bert J.C., et al.
Publicado: (2012)

Interactions between semaphorins and plexin–neuropilin receptor complexes in the membranes of live cells
por: Christie, Shaun M., et al.
Publicado: (2021)

MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy
por: Yao, Hang-Ping, et al.
Publicado: (2020)

Plexin-Semaphorin Signaling Modifies Neuromuscular Defects in a Drosophila Model of Peripheral Neuropathy
por: Grice, Stuart J., et al.
Publicado: (2018)

Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance
por: Mitsogiannis, Manuela D., et al.
Publicado: (2017)

Semaphorin 4D/Plexin-B1–mediated R-Ras GAP activity inhibits cell migration by regulating β(1) integrin activity
por: Oinuma, Izumi, et al.
Publicado: (2006)

Semaphorin 3E–Plexin-D1 signaling controls pathway-specific synapse formation in the striatum
por: Ding, Jun B., et al.
Publicado: (2011)

Transmembrane Recognition of the Semaphorin Co-Receptors Neuropilin 1 and Plexin A1: Coarse-Grained Simulations
por: Aci-Sèche, Samia, et al.
Publicado: (2014)

The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer
por: Ikeya, Tetsuro, et al.
Publicado: (2016)

Characterization of Class-3 Semaphorin Receptors, Neuropilins and Plexins, as Therapeutic Targets in a Pan-Cancer Study
por: Zhang, Xiaoli, et al.
Publicado: (2020)

Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis
por: Yang, Wan-Jen, et al.
Publicado: (2015)

Inhibition of the Semaphorin 4D-Plexin-B1 axis prevents calcification in vascular smooth muscle cells
por: Park, Hyun-Joo, et al.
Publicado: (2023)

Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer
por: Feng, Liang, et al.
Publicado: (2016)

Estrogen-Dependent Proteolytic Cleavage of Semaphorin 4D and Plexin-B1 Enhances Semaphorin 4D-Induced Apoptosis during Postnatal Vaginal Remodeling in Pubescent Mice
por: Ito, Takuji, et al.
Publicado: (2014)

Ron Knockdown and Ron Monoclonal Antibody IMC-RON8 Sensitize Pancreatic Cancer to Histone Deacetylase Inhibitors (HDACi)
por: Zou, Yi, et al.
Publicado: (2013)

Semaphorin-4D (Sema-4D), the Plexin-B1 ligand, is involved in mouse ovary follicular development
por: Regev, Avital, et al.
Publicado: (2007)

Plexin-A4–semaphorin 3A signaling is required for Toll-like receptor– and sepsis-induced cytokine storm
por: Wen, Haitao, et al.
Publicado: (2010)

New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation
por: Mata, Agata, et al.
Publicado: (2018)

Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain
por: Paldy, Eszter, et al.
Publicado: (2017)

The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology
por: Simonetti, Manuela, et al.
Publicado: (2019)

Semaphorin4A promotes lung cancer by activation of NF-κB pathway mediated by PlexinB1
por: Wei, Xiang, et al.
Publicado: (2023)

Erratum to: Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer
por: Feng, Liang, et al.
Publicado: (2016)

Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism
por: Bron, Romke, et al.
Publicado: (2007)

Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery
por: Maruyama, Kazuaki, et al.
Publicado: (2021)

Semaphorin3A/PlexinA3 association with the Scribble scaffold for cGMP increase is required for apical dendrite development
por: Szczurkowska, Joanna, et al.
Publicado: (2022)

Glial and Neuronal Neuroglian, Semaphorin-1a and Plexin A Regulate Morphological and Functional Differentiation of Drosophila Insulin-Producing Cells
por: Clements, Jason, et al.
Publicado: (2021)

Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic variant RON160
por: Lu, Yi, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ra4d602gek8d82askrigcd33bg