Quantitative MNase-seq accurately maps nucleosome occupancy levels

Micrococcal nuclease (MNase) is widely used to map nucleosomes. However, its aggressive endo-/exo-nuclease activities make MNase-seq unreliable for determining nucleosome occupancies, because cleavages within linker regions produce oligo- and mono-nucleosomes, whereas cleavages within nucleosomes de...

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Detalles Bibliográficos
Autores principales: Chereji, Răzvan V., Bryson, Terri D., Henikoff, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743174/
https://www.ncbi.nlm.nih.gov/pubmed/31519205
http://dx.doi.org/10.1186/s13059-019-1815-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743174/
https://www.ncbi.nlm.nih.gov/pubmed/31519205
http://dx.doi.org/10.1186/s13059-019-1815-z

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