Targeting viral entry as a strategy for broad-spectrum antivirals

The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our understanding of the routes and mechanisms of entry for a number of these viruses. This has led to the development of novel broad-spectrum antiviral ap...

Descripción completa

Detalles Bibliográficos
Autores principales: Mazzon, Michela, Marsh, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743247/
https://www.ncbi.nlm.nih.gov/pubmed/31559009
http://dx.doi.org/10.12688/f1000research.19694.1
_version_ 1783451248936091648
author Mazzon, Michela
Marsh, Mark
author_facet Mazzon, Michela
Marsh, Mark
author_sort Mazzon, Michela
collection PubMed
description The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our understanding of the routes and mechanisms of entry for a number of these viruses. This has led to the development of novel broad-spectrum antiviral approaches that target host cell proteins and pathways, in addition to strategies focused on individual viruses or virus families. Here we consider a number of these approaches and their broad-spectrum potential.
format Online
Article
Text
id pubmed-6743247
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher F1000 Research Limited
record_format MEDLINE/PubMed
spelling pubmed-67432472019-09-25 Targeting viral entry as a strategy for broad-spectrum antivirals Mazzon, Michela Marsh, Mark F1000Res Review The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our understanding of the routes and mechanisms of entry for a number of these viruses. This has led to the development of novel broad-spectrum antiviral approaches that target host cell proteins and pathways, in addition to strategies focused on individual viruses or virus families. Here we consider a number of these approaches and their broad-spectrum potential. F1000 Research Limited 2019-09-12 /pmc/articles/PMC6743247/ /pubmed/31559009 http://dx.doi.org/10.12688/f1000research.19694.1 Text en Copyright: © 2019 Mazzon M and Marsh M http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Mazzon, Michela
Marsh, Mark
Targeting viral entry as a strategy for broad-spectrum antivirals
title Targeting viral entry as a strategy for broad-spectrum antivirals
title_full Targeting viral entry as a strategy for broad-spectrum antivirals
title_fullStr Targeting viral entry as a strategy for broad-spectrum antivirals
title_full_unstemmed Targeting viral entry as a strategy for broad-spectrum antivirals
title_short Targeting viral entry as a strategy for broad-spectrum antivirals
title_sort targeting viral entry as a strategy for broad-spectrum antivirals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743247/
https://www.ncbi.nlm.nih.gov/pubmed/31559009
http://dx.doi.org/10.12688/f1000research.19694.1
work_keys_str_mv AT mazzonmichela targetingviralentryasastrategyforbroadspectrumantivirals
AT marshmark targetingviralentryasastrategyforbroadspectrumantivirals

Ejemplares similares