Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system

Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions that in turn regulate ion secretion, nutrient abs...

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Detalles Bibliográficos
Autores principales: Iwasaki, Mari, Akiba, Yasutada, Kaunitz, Jonathan D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743256/
https://www.ncbi.nlm.nih.gov/pubmed/31559013
http://dx.doi.org/10.12688/f1000research.18039.1
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author Iwasaki, Mari
Akiba, Yasutada
Kaunitz, Jonathan D
author_facet Iwasaki, Mari
Akiba, Yasutada
Kaunitz, Jonathan D
author_sort Iwasaki, Mari
collection PubMed
description Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions that in turn regulate ion secretion, nutrient absorption, gut motility, glycemic control, carcinogenesis, immune responses, and circadian rhythms. Genetic ablation of this peptide and its receptors in mice also provides new insights into the contribution of VIP towards physiological signaling and the pathogenesis of related diseases. Here, we discuss the impact of VIP on gastrointestinal function and diseases based on recent findings, also providing insight into its possible therapeutic application to diabetes, autoimmune diseases and cancer.
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spelling pubmed-67432562019-09-25 Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system Iwasaki, Mari Akiba, Yasutada Kaunitz, Jonathan D F1000Res Review Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions that in turn regulate ion secretion, nutrient absorption, gut motility, glycemic control, carcinogenesis, immune responses, and circadian rhythms. Genetic ablation of this peptide and its receptors in mice also provides new insights into the contribution of VIP towards physiological signaling and the pathogenesis of related diseases. Here, we discuss the impact of VIP on gastrointestinal function and diseases based on recent findings, also providing insight into its possible therapeutic application to diabetes, autoimmune diseases and cancer. F1000 Research Limited 2019-09-12 /pmc/articles/PMC6743256/ /pubmed/31559013 http://dx.doi.org/10.12688/f1000research.18039.1 Text en Copyright: © 2019 Iwasaki M et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions.
spellingShingle Review
Iwasaki, Mari
Akiba, Yasutada
Kaunitz, Jonathan D
Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system
title Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system
title_full Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system
title_fullStr Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system
title_full_unstemmed Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system
title_short Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system
title_sort recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743256/
https://www.ncbi.nlm.nih.gov/pubmed/31559013
http://dx.doi.org/10.12688/f1000research.18039.1
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