Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease

Krüppel-like factor 15 (KLF15) is a zinc-finger transcription factor highly expressed in the glomeruli and interstitial cells of kidneys. An increasing number of studies have demonstrated a critical role for KLF15 in the kidney, involving tubular physiology, podocyte injury, renal fibrosis, and mesa...

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Detalles Bibliográficos
Autores principales: Wang, Lefeng, Lin, Weiqiang, Chen, Jianghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743293/
https://www.ncbi.nlm.nih.gov/pubmed/31523196
http://dx.doi.org/10.7150/ijbs.34838
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author Wang, Lefeng
Lin, Weiqiang
Chen, Jianghua
author_facet Wang, Lefeng
Lin, Weiqiang
Chen, Jianghua
author_sort Wang, Lefeng
collection PubMed
description Krüppel-like factor 15 (KLF15) is a zinc-finger transcription factor highly expressed in the glomeruli and interstitial cells of kidneys. An increasing number of studies have demonstrated a critical role for KLF15 in the kidney, involving tubular physiology, podocyte injury, renal fibrosis, and mesangial pathology. In this review, we discuss recent advances and update our overview of the functions of KLF15 in kidney biology, hoping to provide new perspectives on the progression and therapy of Chronic Kidney Disease (CKD). A better understanding of KLF15 with respect to its diverse roles in specific cells or diseases will be beneficial in pursuing novel therapeutic targets and moving forward to precision medicine.
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spelling pubmed-67432932019-09-14 Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease Wang, Lefeng Lin, Weiqiang Chen, Jianghua Int J Biol Sci Review Krüppel-like factor 15 (KLF15) is a zinc-finger transcription factor highly expressed in the glomeruli and interstitial cells of kidneys. An increasing number of studies have demonstrated a critical role for KLF15 in the kidney, involving tubular physiology, podocyte injury, renal fibrosis, and mesangial pathology. In this review, we discuss recent advances and update our overview of the functions of KLF15 in kidney biology, hoping to provide new perspectives on the progression and therapy of Chronic Kidney Disease (CKD). A better understanding of KLF15 with respect to its diverse roles in specific cells or diseases will be beneficial in pursuing novel therapeutic targets and moving forward to precision medicine. Ivyspring International Publisher 2019-07-21 /pmc/articles/PMC6743293/ /pubmed/31523196 http://dx.doi.org/10.7150/ijbs.34838 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Wang, Lefeng
Lin, Weiqiang
Chen, Jianghua
Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease
title Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease
title_full Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease
title_fullStr Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease
title_full_unstemmed Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease
title_short Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease
title_sort krüppel-like factor 15: a potential therapeutic target for kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743293/
https://www.ncbi.nlm.nih.gov/pubmed/31523196
http://dx.doi.org/10.7150/ijbs.34838
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